NTF4 [The Human Chemical-Genetic Interaction Map Project]

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======= NTF4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NTF4
  * **<color #00a2e8>Official Name</color>**: neurotrophin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4909|4909]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P34130|P34130]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NTF4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NTF4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/162662|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3  prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Target-derived survival factor for peripheral sensory sympathetic neurons.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sensory organ boundary specification|
|taste bud development|
|formation of animal organ boundary|
|ganglion mother cell fate determination|
|stem cell fate determination|
|formation of anatomical boundary|
|stem cell fate commitment|
|nerve growth factor signaling pathway|
|neurotrophin TRK receptor signaling pathway|
|tongue development|
|innervation|
|neurotrophin signaling pathway|
|activation of phospholipase C activity|
|long-term memory|
|animal organ formation|
|cell fate determination|
|positive regulation of phospholipase C activity|
|regulation of phospholipase C activity|
|cellular response to nerve growth factor stimulus|
|response to nerve growth factor|
|mechanoreceptor differentiation|
|positive regulation of phospholipase activity|
|positive regulation of lipase activity|
|regulation of phospholipase activity|
|peripheral nervous system development|
|adult locomotory behavior|
|nerve development|
|regulation of lipase activity|
|memory|
|synaptic vesicle|
|adult behavior|
|negative regulation of neuron apoptotic process|
|stem cell differentiation|
|growth factor activity|
|locomotory behavior|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|cell fate commitment|
|cytoplasmic vesicle|
|learning or memory|
|axon|
|cognition|
|regulation of neuron death|
|regionalization|
|epidermis development|
|dendrite|
|pattern specification process|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|response to growth factor|
|sensory organ development|
|behavior|
|regulation of neuron differentiation|
|neuron projection development|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|positive regulation of hydrolase activity|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|negative regulation of cell death|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|nervous system process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|neurogenesis|
|cell development|
|regulation of cell death|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2836
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NTF4 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>