NTN4 [The Human Chemical-Genetic Interaction Map Project]

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======= NTN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NTN4
  * **<color #00a2e8>Official Name</color>**: netrin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59277|59277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HB63|Q9HB63]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NTN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NTN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610401|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin N|
|NTR|
|Laminin EGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling|
|extracellular matrix-cell signaling|
|laminin complex|
|laminin-1 binding|
|basement membrane assembly|
|regulation of branching involved in salivary gland morphogenesis|
|neuron remodeling|
|basement membrane organization|
|neuron maturation|
|substrate adhesion-dependent cell spreading|
|regulation of morphogenesis of a branching structure|
|anatomical structure maturation|
|cell maturation|
|regulation of morphogenesis of an epithelium|
|cell-substrate adhesion|
|developmental maturation|
|regulation of animal organ morphogenesis|
|axon guidance|
|neuron projection guidance|
|extracellular matrix organization|
|axonogenesis|
|extracellular structure organization|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12690
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NTN4 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>