NUDC [The Human Chemical-Genetic Interaction Map Project]

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======= NUDC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDC
  * **<color #00a2e8>Official Name</color>**: nuclear distribution C, dynein complex regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10726|10726]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y266|Q9Y266]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610325|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation. {ECO:0000250, ECO:0000269|PubMed:12679384, ECO:0000269|PubMed:12852857}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|unfolded protein binding|
|protein folding|
|cadherin binding|
|microtubule|
|cell division|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.45|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.3|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.91|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.88|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.86|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.84|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.84|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.95|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.02|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.09|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.13|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ubqln1|UBQLN1]]|0.422|
|[[:human genes:v:vdac2|VDAC2]]|0.42|
|[[:human genes:b:bak1|BAK1]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 208/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|5/28|
|bone|4/26|
|breast|12/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|9/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|8/16|
|kidney|11/21|
|liver|8/20|
|lung|22/75|
|lymphocyte|1/16|
|ovary|11/26|
|pancreas|8/24|
|peripheral nervous system|5/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|7/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|8/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 603
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDC Expression in NALM6 Cells: 7.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>