NUDCD1 [The Human Chemical-Genetic Interaction Map Project]

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======= NUDCD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUDCD1
  * **<color #00a2e8>Official Name</color>**: NudC domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84955|84955]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RS6|Q96RS6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUDCD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUDCD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606109|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-3.71|
|[[:results:exp303|39°C R06 exp303]]|-2.4|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.71|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.71|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.72|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.73|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.74|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.75|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.81|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.84|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.88|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.9|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.91|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.91|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.93|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.97|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.99|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.01|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.04|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.07|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.09|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.13|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.14|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.14|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|2.15|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.15|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|2.16|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.34|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.54|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|3.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6341
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUDCD1 Expression in NALM6 Cells: 5.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>