NUF2 [The Human Chemical-Genetic Interaction Map Project]

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======= NUF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUF2
  * **<color #00a2e8>Official Name</color>**: NUF2 component of NDC80 kinetochore complex
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83540|83540]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BZD4|Q9BZD4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611772|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:12438418, PubMed:14654001, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:17535814). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:12438418, ECO:0000269|PubMed:14654001, ECO:0000269|PubMed:15062103, ECO:0000269|PubMed:15235793, ECO:0000269|PubMed:15239953, ECO:0000269|PubMed:15548592, ECO:0000269|PubMed:17535814, ECO:0000269|PubMed:23085020}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nuf2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ndc80 complex|
|condensed nuclear chromosome kinetochore|
|attachment of mitotic spindle microtubules to kinetochore|
|kinetochore organization|
|attachment of spindle microtubules to kinetochore|
|mitotic metaphase plate congression|
|chromosome, centromeric region|
|metaphase plate congression|
|establishment of chromosome localization|
|chromosome localization|
|mitotic spindle organization|
|meiotic chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|sister chromatid segregation|
|mitotic nuclear division|
|meiotic nuclear division|
|spindle organization|
|meiotic cell cycle process|
|nuclear chromosome segregation|
|meiotic cell cycle|
|protein-containing complex binding|
|chromosome segregation|
|nuclear division|
|organelle fission|
|establishment of organelle localization|
|microtubule cytoskeleton organization|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|molecular function|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.03|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.92|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.79|
|[[:results:exp303|39°C R06 exp303]]|1.76|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.78|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.85|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:plk1|PLK1]]|0.496|
|[[:human genes:c:cactin|CACTIN]]|0.465|
|[[:human genes:m:mt1e|MT1E]]|0.437|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.433|
|[[:human genes:p:psmb1|PSMB1]]|0.425|
|[[:human genes:f:fam160a1|FAM160A1]]|0.419|
|[[:human genes:p:psma6|PSMA6]]|0.415|
|[[:human genes:c:cdc73|CDC73]]|0.414|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.413|
|[[:human genes:p:psmd3|PSMD3]]|0.409|
|[[:human genes:f:fam25b|FAM25B]]|0.408|
|[[:human genes:a:aqr|AQR]]|0.408|
|[[:human genes:c:chd4|CHD4]]|0.408|
|[[:human genes:c:cdc6|CDC6]]|0.407|
|[[:human genes:t:tceb3c|TCEB3C]]|0.405|
|[[:human genes:t:tfip11|TFIP11]]|0.404|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 701/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/28|
|bone|24/26|
|breast|30/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|20/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|14/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 624
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUF2 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>