NUMA1 [The Human Chemical-Genetic Interaction Map Project]

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======= NUMA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUMA1
  * **<color #00a2e8>Official Name</color>**: nuclear mitotic apparatus protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4926|4926]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14980|Q14980]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUMA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUMA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164009|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein- dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5- bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitotic spindle organization|
|anastral spindle assembly|
|cortical microtubule|
|regulation of mitotic spindle elongation|
|cytoplasmic microtubule bundle|
|positive regulation of mitotic spindle elongation|
|regulation of protein localization to spindle pole body|
|positive regulation of protein localization to spindle pole body|
|regulation of spindle elongation|
|lateral cell cortex|
|mitotic spindle astral microtubule|
|positive regulation of spindle assembly|
|positive regulation of protein localization to cell cortex|
|microtubule bundle|
|regulation of metaphase plate congression|
|astral microtubule organization|
|regulation of protein localization to cell cortex|
|microtubule minus-end|
|positive regulation of chromosome separation|
|positive regulation of hair follicle development|
|cell cortex region|
|positive regulation of hair cycle|
|mitotic spindle midzone|
|microtubule minus-end binding|
|spindle pole centrosome|
|positive regulation of keratinocyte differentiation|
|microtubule plus-end binding|
|positive regulation of mitotic sister chromatid segregation|
|microtubule plus-end|
|regulation of hair follicle development|
|dynein complex binding|
|positive regulation of epidermal cell differentiation|
|mitotic spindle pole|
|regulation of hair cycle|
|positive regulation of chromosome segregation|
|regulation of spindle assembly|
|extrinsic component of plasma membrane|
|establishment of mitotic spindle orientation|
|positive regulation of microtubule polymerization|
|positive regulation of BMP signaling pathway|
|establishment of mitotic spindle localization|
|disordered domain specific binding|
|positive regulation of microtubule polymerization or depolymerization|
|establishment of spindle orientation|
|spindle microtubule|
|positive regulation of epidermis development|
|regulation of mitotic spindle organization|
|regulation of keratinocyte differentiation|
|regulation of spindle organization|
|establishment of spindle localization|
|spindle localization|
|regulation of microtubule polymerization|
|cytoplasmic microtubule organization|
|positive regulation of mitotic nuclear division|
|tubulin binding|
|lateral plasma membrane|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|regulation of chromosome separation|
|positive regulation of protein localization to cell periphery|
|positive regulation of nuclear division|
|regulation of mitotic sister chromatid segregation|
|positive regulation of organelle assembly|
|mitotic spindle|
|regulation of microtubule polymerization or depolymerization|
|regulation of sister chromatid segregation|
|regulation of epidermis development|
|phosphatidylinositol binding|
|regulation of BMP signaling pathway|
|microtubule bundle formation|
|spindle assembly|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|nuclear matrix|
|regulation of protein localization to cell periphery|
|establishment of cell polarity|
|spindle|
|spindle pole|
|chromosome|
|positive regulation of protein polymerization|
|nucleus organization|
|cell cortex|
|regulation of epithelial cell differentiation|
|positive regulation of mitotic cell cycle|
|spindle organization|
|regulation of mitotic nuclear division|
|positive regulation of chromosome organization|
|regulation of microtubule cytoskeleton organization|
|protein C-terminus binding|
|structural molecule activity|
|regulation of nuclear division|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|positive regulation of intracellular transport|
|positive regulation of cytoskeleton organization|
|regulation of organelle assembly|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|meiotic cell cycle|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|microtubule binding|
|protein domain specific binding|
|positive regulation of protein complex assembly|
|protein-containing complex binding|
|regulation of cellular response to growth factor stimulus|
|chromosome segregation|
|positive regulation of cell cycle process|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|regulation of intracellular transport|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|neuronal cell body|
|positive regulation of cell cycle|
|dendrite|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|cell division|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|organelle localization|
|protein-containing complex|
|mitotic cell cycle process|
|Golgi membrane|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulation of cell cycle process|
|organelle assembly|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|positive regulation of transport|
|cell cycle process|
|regulation of protein localization|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.74|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.7|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.72|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.81|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.87|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|1.87|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.93|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.98|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.05|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.07|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|2.08|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.41|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|2.5|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.68|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.69|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.76|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.79|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.94|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.05|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|3.22|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|4.12|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|4.19|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|4.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp1a3|ATP1A3]]|0.495|
|[[:human genes:c:cbwd3|CBWD3]]|0.47|
|[[:human genes:p:psmc2|PSMC2]]|0.468|
|[[:human genes:c:chd4|CHD4]]|0.467|
|[[:human genes:a:aamp|AAMP]]|0.458|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.451|
|[[:human genes:t:tceb3c|TCEB3C]]|0.451|
|[[:human genes:c:copg1|COPG1]]|0.449|
|[[:human genes:a:atat1|ATAT1]]|0.446|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.445|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.445|
|[[:human genes:d:disp2|DISP2]]|0.444|
|[[:human genes:c:cbwd5|CBWD5]]|0.442|
|[[:human genes:t:ticrr|TICRR]]|0.436|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.431|
|[[:human genes:c:cbwd6|CBWD6]]|0.428|
|[[:human genes:c:clptm1|CLPTM1]]|0.422|
|[[:human genes:r:rpl30|RPL30]]|0.413|
|[[:human genes:c:ccnf|CCNF]]|0.411|
|[[:human genes:n:nckap1l|NCKAP1L]]|0.406|
|[[:human genes:c:ctage4|CTAGE4]]|0.406|
|[[:human genes:u:upf1|UPF1]]|0.406|
|[[:human genes:d:dtl|DTL]]|0.404|
|[[:human genes:o:orc1|ORC1]]|0.402|
|[[:human genes:m:med15|MED15]]|0.401|
|[[:human genes:a:atp1b3|ATP1B3]]|0.401|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.401|
|[[:human genes:c:ccna2|CCNA2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 19/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 554
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUMA1 Expression in NALM6 Cells: 9.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>