NUMB [The Human Chemical-Genetic Interaction Map Project]

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======= NUMB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUMB
  * **<color #00a2e8>Official Name</color>**: NUMB endocytic adaptor protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8650|8650]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49757|P49757]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUMB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUMB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603728|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NumbF|
|PID|
|PTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuroblast division in subventricular zone|
|forebrain neuroblast division|
|alpha-catenin binding|
|lateral ventricle development|
|regulation of postsynaptic neurotransmitter receptor internalization|
|neuroblast division|
|neuronal stem cell division|
|negative regulation of protein localization to plasma membrane|
|somatic stem cell division|
|negative regulation of protein localization to cell periphery|
|ventricular system development|
|cell proliferation in forebrain|
|extrinsic component of plasma membrane|
|negative regulation of protein localization to membrane|
|neuroblast proliferation|
|stem cell division|
|stem cell proliferation|
|regulation of receptor internalization|
|clathrin-coated vesicle|
|forebrain generation of neurons|
|apical part of cell|
|neural precursor cell proliferation|
|adherens junction organization|
|beta-catenin binding|
|regulation of protein localization to plasma membrane|
|regulation of receptor-mediated endocytosis|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|regulation of protein localization to membrane|
|basolateral plasma membrane|
|regulation of endocytosis|
|cell junction organization|
|early endosome|
|telencephalon development|
|cadherin binding|
|glutamatergic synapse|
|axonogenesis|
|forebrain development|
|axon development|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|positive regulation of cell migration|
|cell part morphogenesis|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|neuron projection development|
|regulation of protein transport|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of protein localization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of developmental process|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-3.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4611
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUMB Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>