NUP133 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP133 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP133
  * **<color #00a2e8>Official Name</color>**: nucleoporin 133
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55746|55746]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUM0|Q8WUM0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP133&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP133|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607613|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nucleoporin C|
|Nucleoporin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore distribution|
|nuclear pore localization|
|condensed chromosome outer kinetochore|
|nuclear pore outer ring|
|nuclear pore organization|
|paraxial mesoderm development|
|cellular protein-containing complex localization|
|structural constituent of nuclear pore|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|somite development|
|localization within membrane|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|condensed chromosome kinetochore|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|protein import into nucleus|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|mesoderm development|
|ribonucleoprotein complex export from nucleus|
|nephron development|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|nucleus organization|
|protein import|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|neural tube development|
|protein localization to nucleus|
|nuclear envelope|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|mesenchyme development|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|kidney development|
|renal system development|
|peptidyl-lysine modification|
|urogenital system development|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|tube development|
|peptidyl-amino acid modification|
|embryo development|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|epithelium development|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.43|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.24|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.04|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.99|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|1.74|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.8|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.81|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.81|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.82|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.87|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.88|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.91|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.91|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.92|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.02|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|2.03|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|2.03|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.28|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|2.55|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps28|RPS28]]|0.506|
|[[:human genes:v:vasn|VASN]]|0.505|
|[[:human genes:r:rps12|RPS12]]|0.496|
|[[:human genes:p:psma7|PSMA7]]|0.486|
|[[:human genes:k:kif3c|KIF3C]]|0.481|
|[[:human genes:c:ccna2|CCNA2]]|0.473|
|[[:human genes:c:chd4|CHD4]]|0.464|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.461|
|[[:human genes:c:cbwd3|CBWD3]]|0.46|
|[[:human genes:c:cbwd5|CBWD5]]|0.459|
|[[:human genes:k:kctd17|KCTD17]]|0.455|
|[[:human genes:t:ttk|TTK]]|0.452|
|[[:human genes:t:twistnb|TWISTNB]]|0.452|
|[[:human genes:p:pola1|POLA1]]|0.449|
|[[:human genes:m:mylk3|MYLK3]]|0.448|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.447|
|[[:human genes:p:psmb4|PSMB4]]|0.447|
|[[:human genes:r:rps2|RPS2]]|0.446|
|[[:human genes:c:cbwd6|CBWD6]]|0.445|
|[[:human genes:c:cdc6|CDC6]]|0.443|
|[[:human genes:p:ppfia4|PPFIA4]]|0.441|
|[[:human genes:d:dido1|DIDO1]]|0.439|
|[[:human genes:g:golga8j|GOLGA8J]]|0.439|
|[[:human genes:b:bysl|BYSL]]|0.436|
|[[:human genes:l:lrr1|LRR1]]|0.436|
|[[:human genes:l:lad1|LAD1]]|0.434|
|[[:human genes:r:rbbp5|RBBP5]]|0.434|
|[[:human genes:t:terf2|TERF2]]|0.432|
|[[:human genes:n:nfatc4|NFATC4]]|0.431|
|[[:human genes:g:golga8o|GOLGA8O]]|0.43|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.428|
|[[:human genes:p:psmd1|PSMD1]]|0.428|
|[[:human genes:p:psmd11|PSMD11]]|0.426|
|[[:human genes:p:psmc1|PSMC1]]|0.426|
|[[:human genes:r:rpl7a|RPL7A]]|0.425|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.423|
|[[:human genes:r:rpl35|RPL35]]|0.422|
|[[:human genes:c:col2a1|COL2A1]]|0.421|
|[[:human genes:s:snrpa1|SNRPA1]]|0.421|
|[[:human genes:a:aamp|AAMP]]|0.42|
|[[:human genes:r:rpsa|RPSA]]|0.418|
|[[:human genes:c:cope|COPE]]|0.417|
|[[:human genes:d:dtl|DTL]]|0.417|
|[[:human genes:p:psmd2|PSMD2]]|0.415|
|[[:human genes:s:sf3a1|SF3A1]]|0.415|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.415|
|[[:human genes:x:xylt2|XYLT2]]|0.414|
|[[:human genes:p:psmb1|PSMB1]]|0.414|
|[[:human genes:p:psmd7|PSMD7]]|0.413|
|[[:human genes:p:psma6|PSMA6]]|0.413|
|[[:human genes:e:elmod3|ELMOD3]]|0.413|
|[[:human genes:o:orc6|ORC6]]|0.413|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.413|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.412|
|[[:human genes:p:polr2f|POLR2F]]|0.412|
|[[:human genes:h:hivep3|HIVEP3]]|0.412|
|[[:human genes:p:psma1|PSMA1]]|0.412|
|[[:human genes:r:rps5|RPS5]]|0.41|
|[[:human genes:s:slc6a17|SLC6A17]]|0.41|
|[[:human genes:p:psmc2|PSMC2]]|0.41|
|[[:human genes:l:lipe|LIPE]]|0.41|
|[[:human genes:n:nupl1|NUPL1]]|0.408|
|[[:human genes:s:ssh2|SSH2]]|0.408|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.408|
|[[:human genes:z:zfand5|ZFAND5]]|0.406|
|[[:human genes:m:madcam1|MADCAM1]]|0.406|
|[[:human genes:o:orc1|ORC1]]|0.404|
|[[:human genes:c:cdc73|CDC73]]|0.404|
|[[:human genes:c:c2orf27a|C2orf27A]]|0.404|
|[[:human genes:p:pola2|POLA2]]|0.404|
|[[:human genes:n:nop16|NOP16]]|0.403|
|[[:human genes:g:gar1|GAR1]]|0.402|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.4|
|[[:human genes:p:psmb3|PSMB3]]|0.4|
|[[:human genes:t:traip|TRAIP]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 725/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|33/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 763
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP133 Expression in NALM6 Cells: 6.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>