NUP155 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP155 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP155
  * **<color #00a2e8>Official Name</color>**: nucleoporin 155
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9631|9631]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75694|O75694]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP155&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP155|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606694|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. {ECO:0000250|UniProtKB:Q99P88}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nucleoporin C|
|Nucleoporin N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to nuclear inner membrane|
|nuclear pore inner ring|
|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|
|protein localization to nuclear envelope|
|atrial cardiac muscle cell action potential|
|atrial cardiac muscle cell to AV node cell signaling|
|atrial cardiac muscle cell to AV node cell communication|
|cell-cell signaling involved in cardiac conduction|
|structural constituent of nuclear pore|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|cardiac muscle cell action potential involved in contraction|
|transporter activity|
|cardiac muscle cell contraction|
|cell communication involved in cardiac conduction|
|cardiac muscle cell action potential|
|nuclear envelope organization|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|cardiac muscle contraction|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|regulation of gene silencing by miRNA|
|heart contraction|
|regulation of carbohydrate catabolic process|
|actin-mediated cell contraction|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|cardiac conduction|
|action potential|
|protein import into nucleus|
|heart process|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|striated muscle contraction|
|actin filament-based movement|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|nucleus organization|
|multicellular organismal signaling|
|protein import|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|nuclear envelope|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|regulation of heart contraction|
|muscle contraction|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|regulation of blood circulation|
|muscle system process|
|peptidyl-lysine modification|
|blood circulation|
|circulatory system process|
|endomembrane system organization|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|protein localization to membrane|
|actin filament-based process|
|regulation of system process|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|membrane organization|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|chromosome organization|
|cell-cell signaling|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|-2.11|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.91|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.9|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.85|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.71|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.71|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.76|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|1.76|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.78|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.82|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.85|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|2.05|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|2.12|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.18|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.22|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|2.22|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.25|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.28|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.34|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.5|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|2.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ckap5|CKAP5]]|0.484|
|[[:human genes:n:nupl1|NUPL1]]|0.475|
|[[:human genes:r:rad21|RAD21]]|0.47|
|[[:human genes:r:rnf4|RNF4]]|0.468|
|[[:human genes:c:cope|COPE]]|0.462|
|[[:human genes:c:c14orf93|C14orf93]]|0.46|
|[[:human genes:s:supt6h|SUPT6H]]|0.459|
|[[:human genes:v:vasn|VASN]]|0.457|
|[[:human genes:i:iscu|ISCU]]|0.451|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.437|
|[[:human genes:n:nup205|NUP205]]|0.435|
|[[:human genes:c:cwc22|CWC22]]|0.434|
|[[:human genes:t:tfip11|TFIP11]]|0.428|
|[[:human genes:n:nup160|NUP160]]|0.425|
|[[:human genes:m:mdm2|MDM2]]|0.424|
|[[:human genes:p:pola1|POLA1]]|0.421|
|[[:human genes:m:med17|MED17]]|0.42|
|[[:human genes:c:cbwd5|CBWD5]]|0.416|
|[[:human genes:n:ndc1|NDC1]]|0.415|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.414|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.412|
|[[:human genes:p:polr2j3|POLR2J3]]|0.412|
|[[:human genes:s:sf3b3|SF3B3]]|0.411|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.407|
|[[:human genes:s:snrpa1|SNRPA1]]|0.405|
|[[:human genes:c:copg1|COPG1]]|0.403|
|[[:human genes:c:cdca3|CDCA3]]|0.401|
|[[:human genes:o:orc1|ORC1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 113/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|3/28|
|bone|6/26|
|breast|3/33|
|central nervous system|17/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|2/21|
|liver|7/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|4/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|1/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP155 Expression in NALM6 Cells: 7.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>