NUP214 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP214 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP214
  * **<color #00a2e8>Official Name</color>**: nucleoporin 214
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8021|8021]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35658|P35658]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP214&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP214|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex. {ECO:0000303|PubMed:8108440}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic side of nuclear pore|
|nuclear export signal receptor activity|
|nuclear localization sequence binding|
|structural constituent of nuclear pore|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|protein import into nucleus|
|regulation of nucleocytoplasmic transport|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|import into nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|protein import|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|regulation of mRNA stability|
|regulation of RNA stability|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|regulation of mRNA catabolic process|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|peptidyl-lysine modification|
|regulation of mRNA metabolic process|
|regulation of intracellular transport|
|focal adhesion|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|posttranscriptional regulation of gene expression|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|viral process|
|protein localization to organelle|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of cell cycle|
|cell cycle|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.84|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|1.77|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.78|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.86|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.87|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|1.89|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|1.98|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.04|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.32|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.428|
|[[:human genes:p:psmd3|PSMD3]]|0.423|
|[[:human genes:p:psma6|PSMA6]]|0.418|
|[[:human genes:c:cdca3|CDCA3]]|0.417|
|[[:human genes:n:nup153|NUP153]]|0.412|
|[[:human genes:c:copg1|COPG1]]|0.407|
|[[:human genes:s:supt6h|SUPT6H]]|0.406|
|[[:human genes:t:tceb3c|TCEB3C]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 267/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|7/28|
|blood|8/28|
|bone|14/26|
|breast|15/33|
|central nervous system|27/56|
|cervix|0/4|
|colorectal|9/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|6/16|
|kidney|4/21|
|liver|7/20|
|lung|34/75|
|lymphocyte|9/16|
|ovary|16/26|
|pancreas|7/24|
|peripheral nervous system|5/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|9/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 437
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP214 Expression in NALM6 Cells: 6.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>