NUP43 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP43 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP43
  * **<color #00a2e8>Official Name</color>**: nucleoporin 43
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=348995|348995]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFH3|Q8NFH3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP43&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP43|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608141|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. {ECO:0000269|PubMed:17363900}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore outer ring|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|kinetochore|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|condensed chromosome kinetochore|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|protein export from nucleus|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|nuclear envelope|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|chromosome segregation|
|peptidyl-lysine modification|
|regulation of small molecule metabolic process|
|cell division|
|viral process|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|cell cycle|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|-2.01|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|-1.85|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.78|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|1.9|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.11|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.529|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.51|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.51|
|[[:human genes:t:tfip11|TFIP11]]|0.498|
|[[:human genes:p:psmd3|PSMD3]]|0.481|
|[[:human genes:c:cactin|CACTIN]]|0.475|
|[[:human genes:t:top1mt|TOP1MT]]|0.466|
|[[:human genes:r:rpl38|RPL38]]|0.462|
|[[:human genes:u:ubl5|UBL5]]|0.459|
|[[:human genes:t:ticrr|TICRR]]|0.457|
|[[:human genes:n:nupl1|NUPL1]]|0.456|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.455|
|[[:human genes:a:akirin2|AKIRIN2]]|0.454|
|[[:human genes:s:supt6h|SUPT6H]]|0.453|
|[[:human genes:r:rrp15|RRP15]]|0.451|
|[[:human genes:c:cdca3|CDCA3]]|0.449|
|[[:human genes:w:wdr87|WDR87]]|0.448|
|[[:human genes:s:slc4a1|SLC4A1]]|0.446|
|[[:human genes:r:rrn3|RRN3]]|0.437|
|[[:human genes:r:rad51|RAD51]]|0.437|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.436|
|[[:human genes:r:rpl4|RPL4]]|0.434|
|[[:human genes:d:dtl|DTL]]|0.434|
|[[:human genes:s:stil|STIL]]|0.433|
|[[:human genes:t:thoc1|THOC1]]|0.433|
|[[:human genes:a:ankle1|ANKLE1]]|0.433|
|[[:human genes:v:vasn|VASN]]|0.432|
|[[:human genes:n:nip7|NIP7]]|0.431|
|[[:human genes:p:psma6|PSMA6]]|0.43|
|[[:human genes:c:ccdc94|CCDC94]]|0.43|
|[[:human genes:w:wdr43|WDR43]]|0.43|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.427|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.427|
|[[:human genes:t:tspy8|TSPY8]]|0.426|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.426|
|[[:human genes:r:ranbp2|RANBP2]]|0.426|
|[[:human genes:k:krt78|KRT78]]|0.422|
|[[:human genes:k:kctd17|KCTD17]]|0.421|
|[[:human genes:t:tceb3c|TCEB3C]]|0.42|
|[[:human genes:a:ankle2|ANKLE2]]|0.42|
|[[:human genes:t:tgm5|TGM5]]|0.419|
|[[:human genes:o:orc6|ORC6]]|0.419|
|[[:human genes:p:psmd1|PSMD1]]|0.419|
|[[:human genes:c:cdc45|CDC45]]|0.419|
|[[:human genes:n:nol12|NOL12]]|0.417|
|[[:human genes:c:chmp2a|CHMP2A]]|0.415|
|[[:human genes:c:cbwd5|CBWD5]]|0.415|
|[[:human genes:h:hap1|HAP1]]|0.414|
|[[:human genes:c:cdc6|CDC6]]|0.414|
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.412|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.412|
|[[:human genes:p:polr2j|POLR2J]]|0.412|
|[[:human genes:k:kpnb1|KPNB1]]|0.412|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.411|
|[[:human genes:z:zfand5|ZFAND5]]|0.411|
|[[:human genes:p:psmd6|PSMD6]]|0.411|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.411|
|[[:human genes:t:ttc31|TTC31]]|0.411|
|[[:human genes:d:ddtl|DDTL]]|0.41|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.41|
|[[:human genes:r:rpl35|RPL35]]|0.409|
|[[:human genes:r:rps2|RPS2]]|0.408|
|[[:human genes:a:ahctf1|AHCTF1]]|0.408|
|[[:human genes:t:timeless|TIMELESS]]|0.408|
|[[:human genes:s:sart1|SART1]]|0.407|
|[[:human genes:o:orc1|ORC1]]|0.406|
|[[:human genes:c:chmp4b|CHMP4B]]|0.405|
|[[:human genes:c:cbwd3|CBWD3]]|0.404|
|[[:human genes:c:casc5|CASC5]]|0.404|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.403|
|[[:human genes:p:pola2|POLA2]]|0.402|
|[[:human genes:d:ddx23|DDX23]]|0.402|
|[[:human genes:r:rbbp5|RBBP5]]|0.401|
|[[:human genes:l:lrr1|LRR1]]|0.401|
|[[:human genes:z:znf106|ZNF106]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 692/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|24/26|
|breast|32/33|
|central nervous system|53/56|
|cervix|2/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|16/20|
|lung|70/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|23/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 740
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP43 Expression in NALM6 Cells: 6.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>