NUP50 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP50 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP50
  * **<color #00a2e8>Official Name</color>**: nucleoporin 50
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10762|10762]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UKX7|Q9UKX7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP50&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP50|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604646|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:20016008). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:20016008). Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity). {ECO:0000250|UniProtKB:Q9JIH2, ECO:0000269|PubMed:20016008}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ran BP1|
|NUP50|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|Ran GTPase binding|
|tRNA transport|
|ncRNA export from nucleus|
|intracellular transport of virus|
|host cell|
|transport of virus|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|protein import into nucleus|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|protein import|
|protein export from nucleus|
|mRNA transport|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|protein localization to nucleus|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|GTPase activator activity|
|peptidyl-lysine modification|
|positive regulation of GTPase activity|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|regulation of GTPase activity|
|intracellular membrane-bounded organelle|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.552|
|[[:human genes:n:nxt1|NXT1]]|0.493|
|[[:human genes:a:aars|AARS]]|0.457|
|[[:human genes:g:gfpt1|GFPT1]]|0.455|
|[[:human genes:t:triap1|TRIAP1]]|0.444|
|[[:human genes:n:nae1|NAE1]]|0.443|
|[[:human genes:n:nupl2|NUPL2]]|0.432|
|[[:human genes:m:meaf6|MEAF6]]|0.424|
|[[:human genes:t:trmt5|TRMT5]]|0.423|
|[[:human genes:r:rtcb|RTCB]]|0.421|
|[[:human genes:u:uba3|UBA3]]|0.42|
|[[:human genes:t:tti1|TTI1]]|0.414|
|[[:human genes:t:tbp|TBP]]|0.414|
|[[:human genes:t:timm23b|TIMM23B]]|0.414|
|[[:human genes:c:csnk2b|CSNK2B]]|0.413|
|[[:human genes:c:cct7|CCT7]]|0.413|
|[[:human genes:e:eny2|ENY2]]|0.411|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.41|
|[[:human genes:t:thoc6|THOC6]]|0.409|
|[[:human genes:p:polr3h|POLR3H]]|0.405|
|[[:human genes:p:pmm2|PMM2]]|0.403|
|[[:human genes:t:tti2|TTI2]]|0.403|
|[[:human genes:s:seh1l|SEH1L]]|0.402|
|[[:human genes:t:tsen34|TSEN34]]|0.401|
|[[:human genes:p:pelo|PELO]]|0.4|
|[[:human genes:a:alg1|ALG1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2878
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP50 Expression in NALM6 Cells: 7.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>