NUP93 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP93 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP93
  * **<color #00a2e8>Official Name</color>**: nucleoporin 93
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9688|9688]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N1F7|Q8N1F7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP93&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP93|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614351|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (PubMed:26878725). {ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:15703211, ECO:0000269|PubMed:26878725, ECO:0000269|PubMed:9348540}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nic96|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear pore complex assembly|
|positive regulation of SMAD protein signal transduction|
|nuclear pore organization|
|nuclear periphery|
|poly(A)+ mRNA export from nucleus|
|pore complex assembly|
|regulation of SMAD protein signal transduction|
|structural constituent of nuclear pore|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|ncRNA export from nucleus|
|nuclear envelope organization|
|intracellular transport of virus|
|host cell|
|SMAD protein signal transduction|
|transport of virus|
|protein sumoylation|
|multi-organism localization|
|multi-organism transport|
|nuclear pore|
|regulation of glycolytic process|
|regulation of cellular response to heat|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|protein import into nucleus|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|mRNA export from nucleus|
|import into nucleus|
|viral transcription|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|regulation of gene silencing|
|viral gene expression|
|nucleus organization|
|protein import|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|regulation of generation of precursor metabolites and energy|
|protein localization to nucleus|
|nuclear envelope|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|RNA localization|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|renal system development|
|peptidyl-lysine modification|
|urogenital system development|
|endomembrane system organization|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|viral process|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|regulation of cellular response to stress|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|membrane organization|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|intracellular protein transport|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of signal transduction|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.26|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-2.23|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.93|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.71|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.71|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.71|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.82|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|1.83|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.88|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.88|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.99|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.04|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|2.13|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.32|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.43|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.57|
|[[:results:exp16|DABN 2μM R00 exp16]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:igfn1|IGFN1]]|0.463|
|[[:human genes:c:cope|COPE]]|0.441|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.437|
|[[:human genes:p:psmd11|PSMD11]]|0.435|
|[[:human genes:c:ctage4|CTAGE4]]|0.429|
|[[:human genes:m:mbtd1|MBTD1]]|0.428|
|[[:human genes:g:gar1|GAR1]]|0.423|
|[[:human genes:p:prim1|PRIM1]]|0.421|
|[[:human genes:o:orc1|ORC1]]|0.419|
|[[:human genes:p:polr2j3|POLR2J3]]|0.419|
|[[:human genes:t:tspy8|TSPY8]]|0.417|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.417|
|[[:human genes:c:chd4|CHD4]]|0.412|
|[[:human genes:v:vasn|VASN]]|0.411|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.41|
|[[:human genes:p:polr2d|POLR2D]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 733/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1448
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP93 Expression in NALM6 Cells: 7.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>