NUP98 [The Human Chemical-Genetic Interaction Map Project]

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======= NUP98 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NUP98
  * **<color #00a2e8>Official Name</color>**: nucleoporin 98 and 96 precursor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4928|4928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52948|P52948]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUP98&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUP98|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601021|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nup96|
|Nucleoporin2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|
|nuclear pore cytoplasmic filaments|
|telomere tethering at nuclear periphery|
|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|
|nuclear pore complex assembly|
|nuclear pore outer ring|
|nuclear pore nuclear basket|
|nuclear inclusion body|
|telomere localization|
|nuclear periphery|
|nuclear pore organization|
|pore complex assembly|
|positive regulation of mRNA splicing, via spliceosome|
|nuclear localization sequence binding|
|structural constituent of nuclear pore|
|positive regulation of mRNA processing|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA export from nucleus|
|positive regulation of RNA splicing|
|tRNA transport|
|ncRNA export from nucleus|
|transporter activity|
|promoter-specific chromatin binding|
|intracellular transport of virus|
|host cell|
|transport of virus|
|serine-type peptidase activity|
|protein sumoylation|
|multi-organism transport|
|multi-organism localization|
|nuclear pore|
|chromosome localization|
|positive regulation of mRNA metabolic process|
|regulation of cellular response to heat|
|regulation of glycolytic process|
|kinetochore|
|regulation of gene silencing by miRNA|
|regulation of carbohydrate catabolic process|
|regulation of posttranscriptional gene silencing|
|regulation of gene silencing by RNA|
|protein import into nucleus|
|regulation of mRNA splicing, via spliceosome|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|viral transcription|
|import into nucleus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|viral gene expression|
|regulation of gene silencing|
|nucleus organization|
|regulation of RNA splicing|
|regulation of mRNA processing|
|protein import|
|protein export from nucleus|
|mRNA transport|
|ribonucleoprotein complex|
|regulation of generation of precursor metabolites and energy|
|nuclear export|
|mRNA binding|
|protein localization to nucleus|
|nuclear envelope|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|viral life cycle|
|regulation of carbohydrate metabolic process|
|DNA replication|
|RNA localization|
|nuclear membrane|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|nuclear body|
|transcription coactivator activity|
|peptidyl-lysine modification|
|regulation of mRNA metabolic process|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|organelle localization|
|intracellular membrane-bounded organelle|
|viral process|
|regulation of cellular response to stress|
|protein localization to organelle|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|regulation of catabolic process|
|chromosome organization|
|proteolysis|
|RNA binding|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.95|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.95|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.8|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.74|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.7|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|1.7|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.78|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.85|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.99|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.1|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.496|
|[[:human genes:r:rrp7a|RRP7A]]|0.473|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.454|
|[[:human genes:p:psmb4|PSMB4]]|0.45|
|[[:human genes:p:pola1|POLA1]]|0.446|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.433|
|[[:human genes:r:rps12|RPS12]]|0.433|
|[[:human genes:t:tceb3c|TCEB3C]]|0.422|
|[[:human genes:c:cbwd5|CBWD5]]|0.421|
|[[:human genes:p:polr2j3|POLR2J3]]|0.42|
|[[:human genes:p:psmc6|PSMC6]]|0.419|
|[[:human genes:m:myb|MYB]]|0.418|
|[[:human genes:c:cbwd3|CBWD3]]|0.413|
|[[:human genes:r:rps21|RPS21]]|0.409|
|[[:human genes:p:psmb2|PSMB2]]|0.409|
|[[:human genes:r:rpl6|RPL6]]|0.407|
|[[:human genes:p:psma7|PSMA7]]|0.407|
|[[:human genes:p:psma6|PSMA6]]|0.407|
|[[:human genes:r:rrp1|RRP1]]|0.406|
|[[:human genes:r:rps2|RPS2]]|0.404|
|[[:human genes:c:chd4|CHD4]]|0.404|
|[[:human genes:r:rps5|RPS5]]|0.404|
|[[:human genes:f:fam25b|FAM25B]]|0.403|
|[[:human genes:c:cbwd6|CBWD6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 237/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|9/28|
|bone|7/26|
|breast|16/33|
|central nervous system|16/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|6/21|
|liver|8/20|
|lung|19/75|
|lymphocyte|8/16|
|ovary|14/26|
|pancreas|10/24|
|peripheral nervous system|7/16|
|plasma cell|10/15|
|prostate|1/1|
|skin|7/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|11/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1871
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NUP98 Expression in NALM6 Cells: 7.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>