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Ask your administrator if you think this is wrong. ======= NUPL1 ======= == Gene Information == * **<color #00a2e8>Official Symbol</color>**: NUP58 * **<color #00a2e8>Official Name</color>**: nucleoporin 58 * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9818|9818]] * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVL2|Q9BVL2]] * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NUPL1&organism=9606|BioGRID]] * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NUPL1|Open PubMed]] * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607615|Open OMIM]] == Function Summary == * **<color #00a2e8>Entrez Summary</color>**: This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. * **<color #00a2e8>UniProt Summary</color>**: Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. {ECO:0000250|UniProtKB:P70581}. <button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button> <button type='primary' size='sm' modal='GO_terms'>GO Terms</button> <modal id='Pfam_Domains' size='lg' title='Pfam Domains'> No Pfam Domain information is available for this gene. </modal> <modal id='GO_terms' size='lg' title='GO Terms'> |protein heterotrimerization| |nuclear localization sequence binding| |structural constituent of nuclear pore| |protein heterotetramerization| |tRNA export from nucleus| |tRNA-containing ribonucleoprotein complex export from nucleus| |tRNA transport| |ncRNA export from nucleus| |intracellular transport of virus| |protein trimerization| |host cell| |regulation of protein import into nucleus| |transport of virus| |regulation of protein import| |protein sumoylation| |multi-organism localization| |multi-organism transport| |nuclear pore| |regulation of glycolytic process| |regulation of cellular response to heat| |regulation of gene silencing by miRNA| |regulation of carbohydrate catabolic process| |regulation of gene silencing by RNA| |regulation of posttranscriptional gene silencing| |regulation of nucleocytoplasmic transport| |protein heterooligomerization| |mRNA-containing ribonucleoprotein complex export from nucleus| |mRNA export from nucleus| |viral transcription| |regulation of purine nucleotide metabolic process| |regulation of protein localization to nucleus| |regulation of nucleotide metabolic process| |regulation of ATP metabolic process| |ribonucleoprotein complex export from nucleus| |ribonucleoprotein complex localization| |RNA export from nucleus| |regulation of gene silencing| |viral gene expression| |protein export from nucleus| |protein tetramerization| |mRNA transport| |nuclear export| |regulation of generation of precursor metabolites and energy| |nuclear envelope| |RNA transport| |nucleic acid transport| |establishment of RNA localization| |viral life cycle| |regulation of carbohydrate metabolic process| |RNA localization| |regulation of intracellular protein transport| |nuclear membrane| |nucleobase-containing compound transport| |protein-containing complex localization| |nucleocytoplasmic transport| |nuclear transport| |peptidyl-lysine modification| |protein homooligomerization| |regulation of intracellular transport| |regulation of small molecule metabolic process| |protein complex oligomerization| |regulation of cellular protein localization| |viral process| |regulation of protein transport| |regulation of cellular response to stress| |regulation of peptide transport| |regulation of establishment of protein localization| |protein modification by small protein conjugation| |symbiotic process| |interspecies interaction between organisms| |peptidyl-amino acid modification| |regulation of cellular localization| |protein modification by small protein conjugation or removal| |regulation of catabolic process| |intracellular protein transport| |regulation of protein localization| |regulation of response to stress| |protein transport| |intracellular transport| |peptide transport| |protein-containing complex assembly| |amide transport| |cellular protein localization| |regulation of phosphorylation| |cellular macromolecule localization| |establishment of protein localization| |regulation of phosphate metabolic process| |regulation of phosphorus metabolic process| |establishment of localization in cell| |nitrogen compound transport| |protein-containing complex subunit organization| |regulation of transport| |gene expression| </modal> \\ === CRISPR Data === <button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button> <button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button> <button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button> <modal id='Compound_Hit' size='lg' title='Compound Hit'> ^Screen^Score^ |[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.08| |[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.98| |[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.74| |[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|1.76| |[[:results:exp274|Citral 50μM R06 exp274]]|1.86| |[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.91| |[[:results:exp169|BH1 1μM R04 exp169]]|1.92| |[[:results:exp165|RO-3306 3 to 4μM on day4 R04 exp165]]|1.94| |[[:results:exp16|DABN 2μM R00 exp16]]|1.96| |[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.02| </modal> <modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'> ^Gene^Correlation^ |[[:human genes:p:psmb4|PSMB4]]|0.593| |[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.574| |[[:human genes:h:hap1|HAP1]]|0.555| |[[:human genes:c:chd4|CHD4]]|0.552| |[[:human genes:t:tceb3c|TCEB3C]]|0.547| |[[:human genes:t:tbc1d3g|TBC1D3G]]|0.547| |[[:human genes:t:tbc1d3h|TBC1D3H]]|0.547| |[[:human genes:m:mt1e|MT1E]]|0.544| |[[:human genes:d:dtl|DTL]]|0.542| |[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.539| |[[:human genes:p:psmd3|PSMD3]]|0.539| |[[:human genes:i:iscu|ISCU]]|0.537| |[[:human genes:c:cbwd3|CBWD3]]|0.536| |[[:human genes:r:rps2|RPS2]]|0.536| |[[:human genes:t:tceb3cl|TCEB3CL]]|0.535| |[[:human genes:p:psmd1|PSMD1]]|0.534| |[[:human genes:t:tbc1d3f|TBC1D3F]]|0.534| |[[:human genes:c:ccna2|CCNA2]]|0.531| |[[:human genes:v:vasn|VASN]]|0.531| |[[:human genes:s:ssh2|SSH2]]|0.528| |[[:human genes:l:lrr1|LRR1]]|0.527| |[[:human genes:t:ticrr|TICRR]]|0.525| |[[:human genes:c:cdca3|CDCA3]]|0.524| |[[:human genes:t:tfip11|TFIP11]]|0.52| |[[:human genes:p:psma6|PSMA6]]|0.519| |[[:human genes:d:ddtl|DDTL]]|0.519| |[[:human genes:d:dock6|DOCK6]]|0.518| |[[:human genes:p:pole|POLE]]|0.518| |[[:human genes:a:aamp|AAMP]]|0.518| |[[:human genes:a:ankle2|ANKLE2]]|0.516| |[[:human genes:c:copb1|COPB1]]|0.514| |[[:human genes:c:cbwd5|CBWD5]]|0.513| |[[:human genes:c:ccdc64b|CCDC64B]]|0.513| |[[:human genes:f:fbxw9|FBXW9]]|0.512| |[[:human genes:s:syt9|SYT9]]|0.512| |[[:human genes:e:exosc5|EXOSC5]]|0.51| |[[:human genes:p:polr2j3|POLR2J3]]|0.51| |[[:human genes:t:twistnb|TWISTNB]]|0.509| |[[:human genes:r:rps12|RPS12]]|0.509| |[[:human genes:n:nup160|NUP160]]|0.509| |[[:human genes:o:orc1|ORC1]]|0.506| |[[:human genes:t:tbc1d3|TBC1D3]]|0.505| |[[:human genes:p:psmb2|PSMB2]]|0.505| |[[:human genes:h:hist1h2be|HIST1H2BE]]|0.504| |[[:human genes:p:ppfia4|PPFIA4]]|0.503| |[[:human genes:a:akirin2|AKIRIN2]]|0.502| |[[:human genes:z:zfand5|ZFAND5]]|0.502| |[[:human genes:c:cactin|CACTIN]]|0.501| |[[:human genes:t:tspy8|TSPY8]]|0.498| |[[:human genes:k:kctd17|KCTD17]]|0.498| |[[:human genes:s:supt6h|SUPT6H]]|0.498| |[[:human genes:c:cbwd6|CBWD6]]|0.497| |[[:human genes:t:tbc1d3c|TBC1D3C]]|0.497| |[[:human genes:s:snip1|SNIP1]]|0.494| |[[:human genes:s:s1pr4|S1PR4]]|0.494| |[[:human genes:s:sart1|SART1]]|0.494| |[[:human genes:n:npipb5|NPIPB5]]|0.493| |[[:human genes:r:rad21|RAD21]]|0.492| |[[:human genes:z:znf655|ZNF655]]|0.492| |[[:human genes:p:psmc6|PSMC6]]|0.489| |[[:human genes:z:znf830|ZNF830]]|0.489| |[[:human genes:s:sec13|SEC13]]|0.489| |[[:human genes:c:copg1|COPG1]]|0.488| |[[:human genes:c:c14orf93|C14orf93]]|0.487| |[[:human genes:t:tyms|TYMS]]|0.487| |[[:human genes:c:cdc45|CDC45]]|0.486| |[[:human genes:n:nol8|NOL8]]|0.485| |[[:human genes:x:xylt2|XYLT2]]|0.484| |[[:human genes:g:gosr2|GOSR2]]|0.484| |[[:human genes:m:med14|MED14]]|0.483| |[[:human genes:r:rps28|RPS28]]|0.483| |[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.482| |[[:human genes:p:polr2f|POLR2F]]|0.481| |[[:human genes:n:nbpf16|NBPF16]]|0.481| |[[:human genes:d:dnttip2|DNTTIP2]]|0.481| |[[:human genes:s:supt5h|SUPT5H]]|0.48| |[[:human genes:o:orc6|ORC6]]|0.48| |[[:human genes:c:cdc6|CDC6]]|0.479| |[[:human genes:t:tp53tg3b|TP53TG3B]]|0.479| |[[:human genes:t:tp53tg3|TP53TG3]]|0.478| |[[:human genes:t:tp53tg3c|TP53TG3C]]|0.477| |[[:human genes:e:egr2|EGR2]]|0.477| |[[:human genes:g:golga8o|GOLGA8O]]|0.476| |[[:human genes:h:hivep3|HIVEP3]]|0.476| |[[:human genes:o:or10g3|OR10G3]]|0.475| |[[:human genes:n:nup155|NUP155]]|0.475| |[[:human genes:p:pcf11|PCF11]]|0.475| |[[:human genes:i:igfn1|IGFN1]]|0.474| |[[:human genes:s:snrpa1|SNRPA1]]|0.474| |[[:human genes:w:wdr87|WDR87]]|0.473| |[[:human genes:k:krt78|KRT78]]|0.473| |[[:human genes:c:copa|COPA]]|0.472| |[[:human genes:p:psmc1|PSMC1]]|0.472| |[[:human genes:m:med17|MED17]]|0.471| |[[:human genes:p:psmc2|PSMC2]]|0.471| |[[:human genes:a:acsf2|ACSF2]]|0.471| |[[:human genes:r:rpsa|RPSA]]|0.47| |[[:human genes:s:stil|STIL]]|0.47| |[[:human genes:c:cdc73|CDC73]]|0.467| |[[:human genes:n:nbpf10|NBPF10]]|0.466| |[[:human genes:c:cope|COPE]]|0.466| |[[:human genes:r:rps9|RPS9]]|0.465| |[[:human genes:n:nup205|NUP205]]|0.465| |[[:human genes:n:nol10|NOL10]]|0.465| |[[:human genes:t:tbc1d3e|TBC1D3E]]|0.464| |[[:human genes:t:tbc1d3i|TBC1D3I]]|0.464| |[[:human genes:a:acd|ACD]]|0.464| |[[:human genes:t:tsg101|TSG101]]|0.463| |[[:human genes:p:psmd11|PSMD11]]|0.463| |[[:human genes:p:psma7|PSMA7]]|0.463| |[[:human genes:t:tbc1d3l|TBC1D3L]]|0.463| |[[:human genes:m:madcam1|MADCAM1]]|0.463| |[[:human genes:t:tbc1d3k|TBC1D3K]]|0.463| |[[:human genes:t:timeless|TIMELESS]]|0.463| |[[:human genes:n:nop16|NOP16]]|0.462| |[[:human genes:r:rps19bp1|RPS19BP1]]|0.462| |[[:human genes:s:scaf1|SCAF1]]|0.462| |[[:human genes:s:slc4a1|SLC4A1]]|0.461| |[[:human genes:g:golga6l6|GOLGA6L6]]|0.46| |[[:human genes:d:dync1i2|DYNC1I2]]|0.46| |[[:human genes:d:dido1|DIDO1]]|0.46| |[[:human genes:s:slc38a7|SLC38A7]]|0.46| |[[:human genes:r:rrp15|RRP15]]|0.46| |[[:human genes:c:chaf1a|CHAF1A]]|0.459| |[[:human genes:a:arcn1|ARCN1]]|0.459| |[[:human genes:c:ccdc116|CCDC116]]|0.458| |[[:human genes:n:nup43|NUP43]]|0.456| |[[:human genes:p:pigs|PIGS]]|0.454| |[[:human genes:u:usp36|USP36]]|0.453| |[[:human genes:p:psma1|PSMA1]]|0.453| |[[:human genes:n:nup54|NUP54]]|0.452| |[[:human genes:n:nsf|NSF]]|0.451| |[[:human genes:g:gar1|GAR1]]|0.451| |[[:human genes:h:hmgcr|HMGCR]]|0.451| |[[:human genes:p:pan3|PAN3]]|0.45| |[[:human genes:n:nfatc4|NFATC4]]|0.45| |[[:human genes:r:rpl35|RPL35]]|0.449| |[[:human genes:i:ik|IK]]|0.449| |[[:human genes:k:kpnb1|KPNB1]]|0.449| |[[:human genes:g:golga6a|GOLGA6A]]|0.448| |[[:human genes:f:fam25b|FAM25B]]|0.447| |[[:human genes:u:upf1|UPF1]]|0.446| |[[:human genes:c:cebpz|CEBPZ]]|0.446| |[[:human genes:p:pola1|POLA1]]|0.446| |[[:human genes:n:narfl|NARFL]]|0.446| |[[:human genes:t:traip|TRAIP]]|0.445| |[[:human genes:r:rpl34|RPL34]]|0.444| |[[:human genes:p:psmb3|PSMB3]]|0.444| |[[:human genes:a:atp6v1a|ATP6V1A]]|0.443| |[[:human genes:r:rpl6|RPL6]]|0.443| |[[:human genes:f:fam160a1|FAM160A1]]|0.443| |[[:human genes:c:cep192|CEP192]]|0.443| |[[:human genes:p:psmb1|PSMB1]]|0.442| |[[:human genes:r:rangap1|RANGAP1]]|0.442| |[[:human genes:a:aqr|AQR]]|0.441| |[[:human genes:p:paf1|PAF1]]|0.441| |[[:human genes:r:rad51|RAD51]]|0.441| |[[:human genes:a:atp6ap1|ATP6AP1]]|0.44| |[[:human genes:f:fam231c|FAM231C]]|0.44| |[[:human genes:f:fam231a|FAM231A]]|0.439| |[[:human genes:m:msh5|MSH5]]|0.439| |[[:human genes:a:ahctf1|AHCTF1]]|0.438| |[[:human genes:b:bysl|BYSL]]|0.437| |[[:human genes:e:eif4a3|EIF4A3]]|0.437| |[[:human genes:c:ckap5|CKAP5]]|0.436| |[[:human genes:s:slc6a17|SLC6A17]]|0.436| |[[:human genes:x:xpo1|XPO1]]|0.435| |[[:human genes:n:nup153|NUP153]]|0.435| |[[:human genes:z:znf106|ZNF106]]|0.434| |[[:human genes:r:rbbp5|RBBP5]]|0.434| |[[:human genes:l:loc643669|LOC643669]]|0.434| |[[:human genes:h:hinfp|HINFP]]|0.434| |[[:human genes:r:rpl14|RPL14]]|0.434| |[[:human genes:c:chmp2a|CHMP2A]]|0.432| |[[:human genes:d:ddt|DDT]]|0.432| |[[:human genes:r:rilpl2|RILPL2]]|0.432| |[[:human genes:c:copb2|COPB2]]|0.432| |[[:human genes:p:pola2|POLA2]]|0.431| |[[:human genes:m:myo18a|MYO18A]]|0.431| |[[:human genes:e:exosc3|EXOSC3]]|0.43| |[[:human genes:x:xab2|XAB2]]|0.428| |[[:human genes:r:rps5|RPS5]]|0.427| |[[:human genes:s:smtn|SMTN]]|0.427| |[[:human genes:p:polr1a|POLR1A]]|0.427| |[[:human genes:r:rrn3|RRN3]]|0.427| |[[:human genes:m:mdm2|MDM2]]|0.426| |[[:human genes:c:ccdc94|CCDC94]]|0.426| |[[:human genes:a:aaas|AAAS]]|0.426| |[[:human genes:r:rpl26|RPL26]]|0.426| |[[:human genes:s:slc23a3|SLC23A3]]|0.426| |[[:human genes:g:golga8j|GOLGA8J]]|0.426| |[[:human genes:g:gon4l|GON4L]]|0.425| |[[:human genes:g:golga6l4|GOLGA6L4]]|0.425| |[[:human genes:s:sult2b1|SULT2B1]]|0.425| |[[:human genes:p:plk1|PLK1]]|0.424| |[[:human genes:v:vps28|VPS28]]|0.424| |[[:human genes:g:golga6l3|GOLGA6L3]]|0.424| |[[:human genes:r:rbm39|RBM39]]|0.423| |[[:human genes:r:ranbp2|RANBP2]]|0.422| |[[:human genes:p:psmc4|PSMC4]]|0.422| |[[:human genes:g:golga8k|GOLGA8K]]|0.422| |[[:human genes:r:rfpl3|RFPL3]]|0.421| |[[:human genes:t:tp53tg3d|TP53TG3D]]|0.421| |[[:human genes:c:csnk1a1|CSNK1A1]]|0.42| |[[:human genes:a:atp6ap2|ATP6AP2]]|0.42| |[[:human genes:p:psmd2|PSMD2]]|0.42| |[[:human genes:p:pwp2|PWP2]]|0.42| |[[:human genes:t:tuba8|TUBA8]]|0.42| |[[:human genes:c:cdca5|CDCA5]]|0.42| |[[:human genes:c:copz1|COPZ1]]|0.419| |[[:human genes:a:aldh1b1|ALDH1B1]]|0.419| |[[:human genes:p:psmd7|PSMD7]]|0.417| |[[:human genes:s:sap30bp|SAP30BP]]|0.416| |[[:human genes:p:pan2|PAN2]]|0.416| |[[:human genes:s:smg7|SMG7]]|0.416| |[[:human genes:n:napa|NAPA]]|0.415| |[[:human genes:r:rnf4|RNF4]]|0.415| |[[:human genes:s:sema6b|SEMA6B]]|0.414| |[[:human genes:f:fcn2|FCN2]]|0.414| |[[:human genes:p:parp3|PARP3]]|0.414| |[[:human genes:m:myo1h|MYO1H]]|0.414| |[[:human genes:s:snrnp200|SNRNP200]]|0.413| |[[:human genes:r:rps11|RPS11]]|0.413| |[[:human genes:n:nup107|NUP107]]|0.413| |[[:human genes:n:ndc80|NDC80]]|0.413| |[[:human genes:h:hist2h3a|HIST2H3A]]|0.412| |[[:human genes:r:rpl7l1|RPL7L1]]|0.412| |[[:human genes:h:hist2h3c|HIST2H3C]]|0.412| |[[:human genes:b:bid|BID]]|0.412| |[[:human genes:c:cwc22|CWC22]]|0.411| |[[:human genes:n:nup85|NUP85]]|0.411| |[[:human genes:s:sf3a1|SF3A1]]|0.411| |[[:human genes:z:znf541|ZNF541]]|0.411| |[[:human genes:u:uqcrh|UQCRH]]|0.411| |[[:human genes:m:mcoln1|MCOLN1]]|0.41| |[[:human genes:c:cdt1|CDT1]]|0.41| |[[:human genes:r:rfxank|RFXANK]]|0.41| |[[:human genes:a:ankle1|ANKLE1]]|0.409| |[[:human genes:r:riok2|RIOK2]]|0.408| |[[:human genes:n:nup133|NUP133]]|0.408| |[[:human genes:p:pde4dip|PDE4DIP]]|0.408| |[[:human genes:k:kif3c|KIF3C]]|0.408| |[[:human genes:d:ddx47|DDX47]]|0.407| |[[:human genes:p:psmd6|PSMD6]]|0.407| |[[:human genes:s:snapc3|SNAPC3]]|0.406| |[[:human genes:p:polr2l|POLR2L]]|0.406| |[[:human genes:p:pole2|POLE2]]|0.405| |[[:human genes:i:itga2b|ITGA2B]]|0.405| |[[:human genes:u:utp3|UTP3]]|0.405| |[[:human genes:n:nol12|NOL12]]|0.404| |[[:human genes:d:ddx56|DDX56]]|0.404| |[[:human genes:p:psmc5|PSMC5]]|0.403| |[[:human genes:s:sh3bp1|SH3BP1]]|0.403| |[[:human genes:c:cdk12|CDK12]]|0.403| |[[:human genes:r:rps7|RPS7]]|0.402| |[[:human genes:h:hnrnpc|HNRNPC]]|0.402| |[[:human genes:p:prim1|PRIM1]]|0.402| |[[:human genes:c:cln6|CLN6]]|0.401| |[[:human genes:g:gbf1|GBF1]]|0.401| |[[:human genes:a:aatf|AATF]]|0.401| |[[:human genes:r:rplp1|RPLP1]]|0.4| |[[:human genes:n:ndc1|NDC1]]|0.4| |[[:human genes:e:exd1|EXD1]]|0.4| |[[:human genes:r:rnpc3|RNPC3]]|0.4| </modal> <modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'> Global Fraction of Cell Lines Where Essential: 2/739 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|0/1| |909776.0|0/1| |bile duct|0/28| |blood|0/28| |bone|0/26| |breast|0/33| |central nervous system|0/56| |cervix|0/4| |colorectal|0/17| |esophagus|0/13| |fibroblast|0/1| |gastric|1/16| |kidney|0/21| |liver|0/20| |lung|0/75| |lymphocyte|0/16| |ovary|0/26| |pancreas|0/24| |peripheral nervous system|0/16| |plasma cell|1/15| |prostate|0/1| |skin|0/24| |soft tissue|0/9| |thyroid|0/2| |upper aerodigestive|0/22| |urinary tract|0/29| |uterus|0/5| </modal> == Essentiality in NALM6 == * **<color #00a2e8>Essentiality Rank</color>**: 1171 * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 <button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button> <modal id='Dist_expr' size='lg' title='NUPL1 Expression in NALM6 Cells: 7.23'> {{:chemogenomics:nalm6 dist.png?nolink |}} </modal> Last modified: 2026/01/07 22:36by 127.0.0.1