NXN [The Human Chemical-Genetic Interaction Map Project]

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======= NXN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: NXN
  * **<color #00a2e8>Official Name</color>**: nucleoredoxin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64359|64359]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6DKJ4|Q6DKJ4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=NXN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20NXN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612895|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AhpC-TSA|
|Redoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-disulfide reductase activity|
|thioredoxin-disulfide reductase activity|
|negative regulation of protein ubiquitination|
|cell redox homeostasis|
|negative regulation of protein modification by small protein conjugation or removal|
|cellular oxidant detoxification|
|cellular detoxification|
|detoxification|
|regulation of protein ubiquitination|
|negative regulation of Wnt signaling pathway|
|cellular response to toxic substance|
|regulation of protein modification by small protein conjugation or removal|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|in utero embryonic development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|response to toxic substance|
|cardiovascular system development|
|negative regulation of protein modification process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|circulatory system development|
|cellular homeostasis|
|oxidation-reduction process|
|embryo development|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13488
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='NXN Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>