OGFOD1 [The Human Chemical-Genetic Interaction Map Project]

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======= OGFOD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OGFOD1
  * **<color #00a2e8>Official Name</color>**: 2-oxoglutarate and iron dependent oxygenase domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55239|55239]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N543|Q8N543]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OGFOD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OGFOD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615857|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation. {ECO:0000269|PubMed:20154146, ECO:0000269|PubMed:24550447, ECO:0000269|PubMed:24550462}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ofd1 CTDD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-proline 3-dioxygenase activity|
|peptidyl-proline dioxygenase activity|
|regulation of translational termination|
|peptidyl-proline hydroxylation|
|stress granule assembly|
|L-ascorbic acid binding|
|protein hydroxylation|
|peptidyl-proline modification|
|cytoplasmic stress granule|
|regulation of protein complex disassembly|
|iron ion binding|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|regulation of translation|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|cell population proliferation|
|organelle assembly|
|cellular protein-containing complex assembly|
|peptidyl-amino acid modification|
|oxidation-reduction process|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.43|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.94|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14402
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OGFOD1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>