OIP5 [The Human Chemical-Genetic Interaction Map Project]

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======= OIP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OIP5
  * **<color #00a2e8>Official Name</color>**: Opa interacting protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11339|11339]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43482|O43482]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OIP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OIP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|chromocenter|
|CENP-A containing nucleosome assembly|
|CENP-A containing chromatin organization|
|chromatin remodeling at centromere|
|centromere complex assembly|
|DNA replication-independent nucleosome assembly|
|DNA replication-independent nucleosome organization|
|histone exchange|
|Cajal body|
|chromosome, centromeric region|
|ATP-dependent chromatin remodeling|
|chromatin|
|nucleosome assembly|
|chromatin assembly|
|chromatin assembly or disassembly|
|nucleosome organization|
|chromatin remodeling|
|DNA packaging|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|chromosome segregation|
|DNA conformation change|
|nuclear speck|
|cell division|
|chromatin organization|
|cellular protein-containing complex assembly|
|chromosome organization|
|identical protein binding|
|cell cycle|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.28|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-2.19|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.09|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.07|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.94|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-1.92|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.87|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-1.86|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.8|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.79|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.79|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.76|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.76|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.567|
|[[:human genes:g:gmppb|GMPPB]]|0.528|
|[[:human genes:a:alg13|ALG13]]|0.488|
|[[:human genes:t:thg1l|THG1L]]|0.486|
|[[:human genes:t:triap1|TRIAP1]]|0.474|
|[[:human genes:d:ddx55|DDX55]]|0.474|
|[[:human genes:u:uap1|UAP1]]|0.471|
|[[:human genes:a:atxn10|ATXN10]]|0.465|
|[[:human genes:y:yars|YARS]]|0.458|
|[[:human genes:r:rptor|RPTOR]]|0.458|
|[[:human genes:o:oraov1|ORAOV1]]|0.457|
|[[:human genes:d:dhps|DHPS]]|0.456|
|[[:human genes:m:med16|MED16]]|0.454|
|[[:human genes:t:tbca|TBCA]]|0.447|
|[[:human genes:u:uxt|UXT]]|0.446|
|[[:human genes:r:rtcb|RTCB]]|0.444|
|[[:human genes:g:gfpt1|GFPT1]]|0.442|
|[[:human genes:d:dpagt1|DPAGT1]]|0.441|
|[[:human genes:t:thoc3|THOC3]]|0.44|
|[[:human genes:r:rnmt|RNMT]]|0.44|
|[[:human genes:d:dr1|DR1]]|0.438|
|[[:human genes:a:alg1|ALG1]]|0.436|
|[[:human genes:p:pelo|PELO]]|0.435|
|[[:human genes:h:hspd1|HSPD1]]|0.43|
|[[:human genes:t:telo2|TELO2]]|0.43|
|[[:human genes:t:tgs1|TGS1]]|0.427|
|[[:human genes:n:nars|NARS]]|0.426|
|[[:human genes:m:mars|MARS]]|0.426|
|[[:human genes:v:vezt|VEZT]]|0.425|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.425|
|[[:human genes:h:hccs|HCCS]]|0.425|
|[[:human genes:a:adsl|ADSL]]|0.423|
|[[:human genes:h:haus8|HAUS8]]|0.422|
|[[:human genes:g:gemin8|GEMIN8]]|0.418|
|[[:human genes:e:exoc4|EXOC4]]|0.415|
|[[:human genes:m:mllt1|MLLT1]]|0.414|
|[[:human genes:p:pmm2|PMM2]]|0.413|
|[[:human genes:r:rpn1|RPN1]]|0.412|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.411|
|[[:human genes:d:dohh|DOHH]]|0.411|
|[[:human genes:e:exoc3|EXOC3]]|0.41|
|[[:human genes:g:gpn2|GPN2]]|0.409|
|[[:human genes:d:dicer1|DICER1]]|0.408|
|[[:human genes:c:casp9|CASP9]]|0.407|
|[[:human genes:d:dpf2|DPF2]]|0.405|
|[[:human genes:u:uhrf1|UHRF1]]|0.404|
|[[:human genes:t:tti2|TTI2]]|0.402|
|[[:human genes:a:abcb7|ABCB7]]|0.401|
|[[:human genes:g:gemin5|GEMIN5]]|0.401|
|[[:human genes:h:hist1h4i|HIST1H4I]]|0.401|
|[[:human genes:m:mis18a|MIS18A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 518/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|23/28|
|blood|15/28|
|bone|15/25|
|breast|18/33|
|central nervous system|39/56|
|cervix|2/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|12/15|
|kidney|13/21|
|liver|17/20|
|lung|52/75|
|lymphocyte|8/14|
|ovary|19/26|
|pancreas|18/24|
|peripheral nervous system|14/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|5/7|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1973
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OIP5 Expression in NALM6 Cells: 4.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>