OPRK1 [The Human Chemical-Genetic Interaction Map Project]

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======= OPRK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OPRK1
  * **<color #00a2e8>Official Name</color>**: opioid receptor kappa 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4986|4986]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41145|P41145]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OPRK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OPRK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/165196|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srx|
|7TM GPCR Srsx|
|7tm 1|
|7TM GPCR Srv|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dynorphin receptor activity|
|adenylate cyclase-inhibiting opioid receptor signaling pathway|
|conditioned place preference|
|response to acrylamide|
|negative regulation of luteinizing hormone secretion|
|positive regulation of eating behavior|
|positive regulation of dopamine secretion|
|receptor serine/threonine kinase binding|
|regulation of luteinizing hormone secretion|
|negative regulation of gonadotropin secretion|
|regulation of eating behavior|
|opioid receptor activity|
|regulation of saliva secretion|
|opioid receptor signaling pathway|
|positive regulation of feeding behavior|
|regulation of gonadotropin secretion|
|maternal behavior|
|parental behavior|
|positive regulation of catecholamine secretion|
|estrous cycle|
|behavioral response to cocaine|
|sensory perception of temperature stimulus|
|neuropeptide binding|
|positive regulation of p38MAPK cascade|
|regulation of feeding behavior|
|positive regulation of behavior|
|eating behavior|
|reproductive behavior|
|positive regulation of response to drug|
|response to morphine|
|response to isoquinoline alkaloid|
|integral component of synaptic vesicle membrane|
|positive regulation of amine transport|
|positive regulation of potassium ion transmembrane transport|
|regulation of sensory perception of pain|
|regulation of digestive system process|
|regulation of dopamine secretion|
|regulation of sensory perception|
|regulation of p38MAPK cascade|
|regulation of endocrine process|
|positive regulation of potassium ion transport|
|integral component of postsynaptic membrane|
|peptide binding|
|axon terminus|
|response to cocaine|
|integral component of presynaptic membrane|
|regulation of catecholamine secretion|
|negative regulation of hormone secretion|
|ovulation cycle|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|regulation of behavior|
|cellular response to monosaccharide stimulus|
|sensory perception of pain|
|response to estrogen|
|associative learning|
|response to anesthetic|
|regulation of potassium ion transmembrane transport|
|cellular response to carbohydrate stimulus|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|feeding behavior|
|cellular glucose homeostasis|
|regulation of amine transport|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of potassium ion transport|
|regulation of response to drug|
|neuropeptide signaling pathway|
|response to alkaloid|
|response to ethanol|
|perikaryon|
|regulation of nervous system process|
|response to glucose|
|positive regulation of cation transmembrane transport|
|response to hexose|
|adult behavior|
|learning|
|response to monosaccharide|
|positive regulation of ion transmembrane transport|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|response to carbohydrate|
|response to ammonium ion|
|glucose homeostasis|
|cellular response to lipopolysaccharide|
|carbohydrate homeostasis|
|defense response to virus|
|cellular response to molecule of bacterial origin|
|locomotory behavior|
|positive regulation of transmembrane transport|
|negative regulation of secretion by cell|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cellular response to biotic stimulus|
|response to insulin|
|negative regulation of secretion|
|response to alcohol|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|learning or memory|
|regulation of hormone secretion|
|positive regulation of ion transport|
|rhythmic process|
|response to virus|
|cognition|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|response to peptide hormone|
|positive regulation of secretion by cell|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|positive regulation of secretion|
|trans-synaptic signaling|
|response to radiation|
|synaptic signaling|
|response to peptide|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of body fluid levels|
|response to toxic substance|
|cellular response to lipid|
|regulation of hormone levels|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|response to bacterium|
|regulation of ion transport|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of secretion|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|defense response to other organism|
|sensory perception|
|regulation of locomotion|
|positive regulation of transport|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|immune effector process|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.87|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17688
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.91 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OPRK1 Expression in NALM6 Cells: 0.91'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>