OPRM1 [The Human Chemical-Genetic Interaction Map Project]

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======= OPRM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OPRM1
  * **<color #00a2e8>Official Name</color>**: opioid receptor mu 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4988|4988]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35372|P35372]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OPRM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OPRM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600018|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srv|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|morphine receptor activity|
|negative regulation of Wnt protein secretion|
|beta-endorphin receptor activity|
|adenylate cyclase-inhibiting opioid receptor signaling pathway|
|spine apparatus|
|positive regulation of appetite|
|regulation of Wnt protein secretion|
|positive regulation of response to food|
|cellular response to morphine|
|cellular response to isoquinoline alkaloid|
|positive regulation of response to nutrient levels|
|positive regulation of response to extracellular stimulus|
|acute inflammatory response to antigenic stimulus|
|adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway|
|negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|opioid receptor signaling pathway|
|adenylate cyclase-activating dopamine receptor signaling pathway|
|behavioral response to ethanol|
|filamin binding|
|regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|estrous cycle|
|regulation of response to food|
|G protein-coupled acetylcholine receptor signaling pathway|
|G-protein beta-subunit binding|
|response to food|
|neuropeptide binding|
|regulation of appetite|
|negative regulation of cAMP-mediated signaling|
|inflammatory response to antigenic stimulus|
|G-protein alpha-subunit binding|
|regulation of response to nutrient levels|
|regulation of response to extracellular stimulus|
|dendrite membrane|
|eating behavior|
|acetylcholine receptor signaling pathway|
|dendrite cytoplasm|
|cellular response to acetylcholine|
|response to acetylcholine|
|response to morphine|
|response to isoquinoline alkaloid|
|cellular response to alkaloid|
|dopamine receptor signaling pathway|
|regulation of NMDA receptor activity|
|regulation of sensory perception of pain|
|postsynaptic signal transduction|
|voltage-gated calcium channel activity|
|regulation of sensory perception|
|integral component of postsynaptic membrane|
|negative regulation of G protein-coupled receptor signaling pathway|
|regulation of cAMP-mediated signaling|
|peptide binding|
|response to cocaine|
|integral component of presynaptic membrane|
|excitatory postsynaptic potential|
|regulation of glutamate receptor signaling pathway|
|ovulation cycle|
|chemical synaptic transmission, postsynaptic|
|acute inflammatory response|
|regulation of neurotransmitter receptor activity|
|sensory perception of pain|
|response to anesthetic|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|cellular response to dopamine|
|feeding behavior|
|response to dopamine|
|signal transduction involved in cellular response to ammonium ion|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|sarcolemma|
|regulation of postsynaptic membrane potential|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|neuropeptide signaling pathway|
|response to catecholamine|
|response to alkaloid|
|response to ethanol|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|cellular response to ammonium ion|
|negative regulation of protein secretion|
|perikaryon|
|regulation of nervous system process|
|negative regulation of peptide secretion|
|regulation of G protein-coupled receptor signaling pathway|
|adult behavior|
|cAMP-mediated signaling|
|regulation of cation channel activity|
|cyclic-nucleotide-mediated signaling|
|regulation of signaling receptor activity|
|negative regulation of protein transport|
|response to ammonium ion|
|negative regulation of establishment of protein localization|
|cellular response to xenobiotic stimulus|
|protein C-terminus binding|
|locomotory behavior|
|calcium ion transmembrane transport|
|negative regulation of secretion by cell|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|membrane raft|
|negative regulation of secretion|
|response to alcohol|
|protein domain specific binding|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|endosome|
|rhythmic process|
|regulation of transporter activity|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|axon|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|cellular response to drug|
|focal adhesion|
|dendrite|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|response to radiation|
|synaptic signaling|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|wound healing|
|negative regulation of transport|
|regulation of peptide secretion|
|response to nutrient levels|
|inflammatory response|
|negative regulation of intracellular signal transduction|
|response to toxic substance|
|response to extracellular stimulus|
|response to growth factor|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|response to wounding|
|regulation of system process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulation of ion transport|
|regulation of protein transport|
|G protein-coupled receptor activity|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of secretion|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|cation transport|
|multicellular organism reproduction|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|sensory perception|
|Golgi apparatus|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-2.22|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|-1.83|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11844
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OPRM1 Expression in NALM6 Cells: 1.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>