OR4F4 [The Human Chemical-Genetic Interaction Map Project]

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======= OR4F4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OR4F4
  * **<color #00a2e8>Official Name</color>**: olfactory receptor family 4 subfamily F member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26682|26682]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96R69|Q96R69]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OR4F4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OR4F4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Odorant receptor. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srsx|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of chemical stimulus involved in sensory perception of smell|
|olfactory receptor activity|
|sensory perception of smell|
|detection of chemical stimulus involved in sensory perception|
|detection of chemical stimulus|
|sensory perception of chemical stimulus|
|detection of stimulus involved in sensory perception|
|detection of stimulus|
|G protein-coupled receptor activity|
|sensory perception|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.12|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.08|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.81|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.79|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.78|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.78|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.71|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.82|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.471|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 574/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|23/28|
|blood|19/28|
|bone|19/26|
|breast|27/33|
|central nervous system|41/56|
|cervix|3/4|
|colorectal|15/17|
|esophagus|7/13|
|fibroblast|0/1|
|gastric|11/16|
|kidney|17/21|
|liver|15/20|
|lung|57/75|
|lymphocyte|12/16|
|ovary|21/26|
|pancreas|21/24|
|peripheral nervous system|16/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|18/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|21/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2729
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OR4F4 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>