ORAI1 [The Human Chemical-Genetic Interaction Map Project]

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======= ORAI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ORAI1
  * **<color #00a2e8>Official Name</color>**: ORAI calcium release-activated calcium modulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84876|84876]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96D31|Q96D31]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ORAI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ORAI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610277|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901). {ECO:0000269|PubMed:16582901, ECO:0000269|PubMed:16645049, ECO:0000269|PubMed:16733527, ECO:0000269|PubMed:16766533, ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:19249086, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:24351972, ECO:0000269|PubMed:24591628, ECO:0000269|PubMed:28219928}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Orai-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|store-operated calcium entry|
|positive regulation of adenylate cyclase activity|
|store-operated calcium channel activity|
|positive regulation of cyclase activity|
|positive regulation of lyase activity|
|regulation of adenylate cyclase activity|
|plasma membrane raft|
|calcium ion import|
|regulation of cyclase activity|
|regulation of lyase activity|
|mammary gland epithelium development|
|positive regulation of calcium ion transport|
|mammary gland development|
|basolateral plasma membrane|
|calcium ion transmembrane transport|
|calmodulin binding|
|membrane raft|
|regulation of calcium ion transport|
|calcium ion transport|
|positive regulation of ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of metal ion transport|
|gland development|
|inorganic cation transmembrane transport|
|protein-containing complex|
|adaptive immune response|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|cation transport|
|ion transmembrane transport|
|positive regulation of transport|
|identical protein binding|
|epithelium development|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|tissue development|
|positive regulation of molecular function|
|regulation of transport|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.587|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15720
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ORAI1 Expression in NALM6 Cells: 3.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>