ORC5 [The Human Chemical-Genetic Interaction Map Project]

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======= ORC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ORC5
  * **<color #00a2e8>Official Name</color>**: origin recognition complex subunit 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5001|5001]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43913|O43913]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ORC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ORC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602331|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|origin recognition complex|
|nuclear origin of replication recognition complex|
|DNA replication origin binding|
|DNA replication initiation|
|nucleotide binding|
|nuclear chromosome, telomeric region|
|G1/S transition of mitotic cell cycle|
|DNA-dependent DNA replication|
|cell cycle G1/S phase transition|
|DNA replication|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|mitotic cell cycle process|
|mitotic cell cycle|
|DNA metabolic process|
|molecular function|
|cell cycle process|
|cell cycle|
|ATP binding|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|-2.49|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.81|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tbca|TBCA]]|0.42|
|[[:human genes:p:pmm2|PMM2]]|0.414|
|[[:human genes:h:hars|HARS]]|0.41|
|[[:human genes:u:uhrf1|UHRF1]]|0.41|
|[[:human genes:a:alg2|ALG2]]|0.407|
|[[:human genes:t:trmt5|TRMT5]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4946
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ORC5 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>