OSGIN2 [The Human Chemical-Genetic Interaction Map Project]

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======= OSGIN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSGIN2
  * **<color #00a2e8>Official Name</color>**: oxidative stress induced growth inhibitor family member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=734|734]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y236|Q9Y236]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSGIN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSGIN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604598|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in meiosis or the maturation of germ cells.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|growth factor activity|
|negative regulation of cell growth|
|meiotic cell cycle|
|negative regulation of growth|
|regulation of cell growth|
|cellular component|
|regulation of growth|
|molecular function|
|cell cycle|
|reproductive process|
|reproduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-3.54|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.69|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.34|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.28|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.13|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.97|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.86|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.8|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.79|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.77|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.78|
|[[:results:exp518|RK-33 8μM R08 exp518]]|7.59|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gclm|GCLM]]|0.64|
|[[:human genes:g:gclc|GCLC]]|0.489|
|[[:human genes:g:gss|GSS]]|0.46|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10687
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSGIN2 Expression in NALM6 Cells: 4.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>