OSR1 [The Human Chemical-Genetic Interaction Map Project]

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======= OSR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSR1
  * **<color #00a2e8>Official Name</color>**: odd-skipped related transcription factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=130497|130497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TAX0|Q8TAX0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608891|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal vesicle progenitor cell differentiation|
|metanephric cap development|
|anterior mesonephric tubule development|
|specification of posterior mesonephric tubule identity|
|metanephric interstitial fibroblast development|
|metanephric cap mesenchymal cell proliferation involved in metanephros development|
|metanephric interstitial fibroblast differentiation|
|metanephric cap morphogenesis|
|specification of mesonephric tubule identity|
|specification of anterior mesonephric tubule identity|
|kidney interstitial fibroblast differentiation|
|negative regulation of creatine transmembrane transporter activity|
|anterior/posterior pattern specification involved in kidney development|
|pattern specification involved in mesonephros development|
|regulation of creatine transmembrane transporter activity|
|kidney smooth muscle tissue development|
|intermediate mesoderm development|
|metanephric smooth muscle tissue development|
|negative regulation of nephron tubule epithelial cell differentiation|
|renal interstitial fibroblast development|
|posterior mesonephric tubule development|
|embryonic skeletal limb joint morphogenesis|
|kidney mesenchyme morphogenesis|
|ureter urothelium development|
|limb joint morphogenesis|
|metanephric mesenchyme morphogenesis|
|pattern specification involved in metanephros development|
|mesonephric duct morphogenesis|
|specification of nephron tubule identity|
|proximal/distal pattern formation involved in nephron development|
|metanephric mesenchymal cell differentiation|
|negative regulation of epithelial cell differentiation involved in kidney development|
|metanephric glomerulus vasculature development|
|mesangial cell development|
|mesangial cell differentiation|
|cell proliferation involved in metanephros development|
|mesonephric tubule formation|
|positive regulation of gastrulation|
|pericyte cell differentiation|
|mesenchymal cell differentiation involved in renal system development|
|mesenchymal cell differentiation involved in kidney development|
|pattern specification involved in kidney development|
|renal system pattern specification|
|pronephros development|
|mesonephric duct development|
|cell proliferation involved in kidney development|
|metanephric glomerulus development|
|embryonic skeletal joint morphogenesis|
|nephric duct morphogenesis|
|negative regulation of sodium ion transmembrane transporter activity|
|regulation of nephron tubule epithelial cell differentiation|
|renal vesicle development|
|negative regulation of sodium ion transmembrane transport|
|negative regulation of anion transmembrane transport|
|metanephric mesenchyme development|
|embryonic skeletal joint development|
|metanephric nephron tubule development|
|ureter development|
|nephric duct development|
|mesenchymal cell proliferation|
|negative regulation of kidney development|
|nephron tubule formation|
|metanephric nephron epithelium development|
|smooth muscle tissue development|
|segment specification|
|cell differentiation involved in metanephros development|
|glomerulus vasculature development|
|kidney mesenchyme development|
|negative regulation of sodium ion transport|
|metanephric tubule development|
|regulation of epithelial cell differentiation involved in kidney development|
|middle ear morphogenesis|
|kidney vasculature development|
|renal system vasculature development|
|negative regulation of organic acid transport|
|metanephric epithelium development|
|regulation of anion transmembrane transport|
|negative regulation of anion transport|
|negative regulation of response to drug|
|embryonic hindlimb morphogenesis|
|metanephric nephron development|
|proximal/distal pattern formation|
|embryonic forelimb morphogenesis|
|hindlimb morphogenesis|
|regulation of gastrulation|
|positive regulation of embryonic development|
|positive regulation of bone mineralization|
|cell differentiation involved in kidney development|
|negative regulation of epithelial cell differentiation|
|forelimb morphogenesis|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|mesenchyme morphogenesis|
|glomerulus development|
|regulation of sodium ion transmembrane transporter activity|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|regulation of organic acid transport|
|embryonic digit morphogenesis|
|regulation of sodium ion transmembrane transport|
|nephron tubule morphogenesis|
|extrinsic component of membrane|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|cellular response to retinoic acid|
|negative regulation of ion transmembrane transporter activity|
|regulation of bone mineralization|
|nephron tubule development|
|negative regulation of transporter activity|
|renal tubule development|
|chondrocyte differentiation|
|negative regulation of cation transmembrane transport|
|metanephros development|
|kidney morphogenesis|
|positive regulation of ossification|
|ureteric bud development|
|mesonephric epithelium development|
|regulation of sodium ion transport|
|mesonephric tubule development|
|roof of mouth development|
|mesonephros development|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|embryonic skeletal system morphogenesis|
|regulation of anion transport|
|negative regulation of ion transmembrane transport|
|segmentation|
|nephron epithelium development|
|regulation of response to drug|
|response to retinoic acid|
|negative regulation of transmembrane transport|
|ear morphogenesis|
|odontogenesis|
|embryonic epithelial tube formation|
|nephron development|
|mesoderm development|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|kidney epithelium development|
|regulation of embryonic development|
|epithelial tube formation|
|regulation of epithelial cell differentiation|
|morphogenesis of embryonic epithelium|
|negative regulation of ion transport|
|tube formation|
|appendage morphogenesis|
|limb morphogenesis|
|mesenchymal cell differentiation|
|stem cell differentiation|
|cartilage development|
|appendage development|
|limb development|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|cellular response to acid chemical|
|gonad development|
|anterior/posterior pattern specification|
|development of primary sexual characteristics|
|mesenchyme development|
|ear development|
|connective tissue development|
|skeletal system morphogenesis|
|sensory organ morphogenesis|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|sex differentiation|
|kidney development|
|regulation of transporter activity|
|renal system development|
|embryonic organ morphogenesis|
|muscle tissue development|
|epithelial tube morphogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|urogenital system development|
|regionalization|
|regulation of cation transmembrane transport|
|regulation of epithelial cell proliferation|
|response to acid chemical|
|regulation of metal ion transport|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|blood vessel development|
|skeletal system development|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|heart development|
|sensory organ development|
|cell population proliferation|
|regulation of transmembrane transport|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of ion transport|
|negative regulation of cell differentiation|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|negative regulation of cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp275|Citral 75μM R06 exp275]]|1.77|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15959
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSR1 Expression in NALM6 Cells: -2.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>