OSTC [The Human Chemical-Genetic Interaction Map Project]

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======= OSTC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OSTC
  * **<color #00a2e8>Official Name</color>**: oligosaccharyltransferase complex non-catalytic subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58505|58505]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRP0|Q9NRP0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OSTC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OSTC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619023|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as substrate-specific component of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. {ECO:0000269|PubMed:21768116, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OST3 OST6|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|
|oligosaccharyltransferase complex|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|protein N-linked glycosylation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|peptidyl-amino acid modification|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.36|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.04|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.01|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.82|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 186/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|11/28|
|blood|1/28|
|bone|9/26|
|breast|3/33|
|central nervous system|10/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|7/20|
|lung|14/75|
|lymphocyte|0/16|
|ovary|6/26|
|pancreas|12/24|
|peripheral nervous system|3/16|
|plasma cell|11/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|12/22|
|urinary tract|10/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8062
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OSTC Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>