OTUD5 [The Human Chemical-Genetic Interaction Map Project]

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======= OTUD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OTUD5
  * **<color #00a2e8>Official Name</color>**: OTU deubiquitinase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55593|55593]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96G74|Q96G74]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OTUD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OTUD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300713|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'- linked ubiquitin chains (in vitro). {ECO:0000269|PubMed:17991829, ECO:0000269|PubMed:22245969, ECO:0000269|PubMed:23827681}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OTU|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitinyl hydrolase activity|
|Lys63-specific deubiquitinase activity|
|Lys48-specific deubiquitinase activity|
|protein K63-linked deubiquitination|
|protein K48-linked deubiquitination|
|negative regulation of type I interferon production|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of type I interferon production|
|negative regulation of cytokine production|
|protein deubiquitination|
|protein modification by small protein removal|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to bacterium|
|regulation of cytokine production|
|response to lipid|
|protein modification by small protein conjugation or removal|
|negative regulation of multicellular organismal process|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-2.39|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.22|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.17|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.9|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.89|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.82|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-1.81|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.72|
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.72|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.73|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.73|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.98|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.08|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.26|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.34|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.36|
|[[:results:exp539|42°C R08 exp539]]|2.37|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.63|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|2.66|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.81|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.87|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|3.11|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ubr5|UBR5]]|0.707|
|[[:human genes:t:tti2|TTI2]]|0.562|
|[[:human genes:m:mllt1|MLLT1]]|0.545|
|[[:human genes:h:hars|HARS]]|0.544|
|[[:human genes:c:ccdc101|CCDC101]]|0.542|
|[[:human genes:v:vcpip1|VCPIP1]]|0.536|
|[[:human genes:r:rptor|RPTOR]]|0.536|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.535|
|[[:human genes:u:ube2l3|UBE2L3]]|0.533|
|[[:human genes:t:tle4|TLE4]]|0.53|
|[[:human genes:a:aars|AARS]]|0.53|
|[[:human genes:c:csnk2b|CSNK2B]]|0.527|
|[[:human genes:m:meaf6|MEAF6]]|0.527|
|[[:human genes:z:znf608|ZNF608]]|0.525|
|[[:human genes:c:cct7|CCT7]]|0.514|
|[[:human genes:m:med23|MED23]]|0.513|
|[[:human genes:t:trmt5|TRMT5]]|0.51|
|[[:human genes:e:eif4e|EIF4E]]|0.509|
|[[:human genes:r:rnmt|RNMT]]|0.505|
|[[:human genes:t:trim28|TRIM28]]|0.5|
|[[:human genes:t:thoc6|THOC6]]|0.499|
|[[:human genes:c:cbx3|CBX3]]|0.498|
|[[:human genes:m:mapk14|MAPK14]]|0.497|
|[[:human genes:n:nae1|NAE1]]|0.493|
|[[:human genes:b:bap1|BAP1]]|0.488|
|[[:human genes:g:gmppb|GMPPB]]|0.487|
|[[:human genes:p:polr3b|POLR3B]]|0.485|
|[[:human genes:i:id3|ID3]]|0.483|
|[[:human genes:h:hhex|HHEX]]|0.48|
|[[:human genes:u:uap1|UAP1]]|0.478|
|[[:human genes:r:rad1|RAD1]]|0.478|
|[[:human genes:s:srp72|SRP72]]|0.475|
|[[:human genes:w:wdr24|WDR24]]|0.475|
|[[:human genes:p:polr3h|POLR3H]]|0.473|
|[[:human genes:t:tmem41b|TMEM41B]]|0.471|
|[[:human genes:c:cbfb|CBFB]]|0.471|
|[[:human genes:n:nars|NARS]]|0.469|
|[[:human genes:t:trip12|TRIP12]]|0.469|
|[[:human genes:v:vrk1|VRK1]]|0.468|
|[[:human genes:a:alg14|ALG14]]|0.462|
|[[:human genes:g:gfpt1|GFPT1]]|0.462|
|[[:human genes:g:gnb1l|GNB1L]]|0.458|
|[[:human genes:r:rtcb|RTCB]]|0.458|
|[[:human genes:d:dpagt1|DPAGT1]]|0.456|
|[[:human genes:t:tti1|TTI1]]|0.455|
|[[:human genes:k:kcmf1|KCMF1]]|0.454|
|[[:human genes:v:vmp1|VMP1]]|0.452|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.451|
|[[:human genes:x:xpo6|XPO6]]|0.448|
|[[:human genes:a:alg5|ALG5]]|0.448|
|[[:human genes:x:xpot|XPOT]]|0.447|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.447|
|[[:human genes:m:mtor|MTOR]]|0.446|
|[[:human genes:p:pmm2|PMM2]]|0.445|
|[[:human genes:t:triap1|TRIAP1]]|0.443|
|[[:human genes:y:yars|YARS]]|0.439|
|[[:human genes:m:med25|MED25]]|0.438|
|[[:human genes:e:exoc4|EXOC4]]|0.437|
|[[:human genes:d:dnajc3|DNAJC3]]|0.435|
|[[:human genes:t:telo2|TELO2]]|0.434|
|[[:human genes:n:nsd1|NSD1]]|0.432|
|[[:human genes:r:rpe|RPE]]|0.43|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.429|
|[[:human genes:f:fbxo11|FBXO11]]|0.427|
|[[:human genes:n:nsmce2|NSMCE2]]|0.427|
|[[:human genes:e:eny2|ENY2]]|0.426|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.426|
|[[:human genes:a:asxl2|ASXL2]]|0.424|
|[[:human genes:d:dhx29|DHX29]]|0.422|
|[[:human genes:u:usp22|USP22]]|0.42|
|[[:human genes:m:med16|MED16]]|0.42|
|[[:human genes:n:nxt1|NXT1]]|0.42|
|[[:human genes:s:srp68|SRP68]]|0.419|
|[[:human genes:g:glmn|GLMN]]|0.419|
|[[:human genes:m:mars|MARS]]|0.419|
|[[:human genes:r:rnf126|RNF126]]|0.419|
|[[:human genes:h:hspd1|HSPD1]]|0.416|
|[[:human genes:u:ube2j1|UBE2J1]]|0.416|
|[[:human genes:a:atf7ip|ATF7IP]]|0.413|
|[[:human genes:c:cars|CARS]]|0.412|
|[[:human genes:b:brpf1|BRPF1]]|0.411|
|[[:human genes:p:ppp4c|PPP4C]]|0.409|
|[[:human genes:d:dhdds|DHDDS]]|0.408|
|[[:human genes:f:fli1|FLI1]]|0.407|
|[[:human genes:s:spcs2|SPCS2]]|0.405|
|[[:human genes:z:znf410|ZNF410]]|0.404|
|[[:human genes:a:alg1|ALG1]]|0.404|
|[[:human genes:u:ube2g1|UBE2G1]]|0.403|
|[[:human genes:t:trnt1|TRNT1]]|0.402|
|[[:human genes:c:cmtr1|CMTR1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 42/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|2/28|
|blood|0/26|
|bone|3/26|
|breast|3/30|
|central nervous system|1/49|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/11|
|fibroblast|0/1|
|gastric|1/14|
|kidney|2/18|
|liver|2/19|
|lung|2/72|
|lymphocyte|0/16|
|ovary|2/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|2/12|
|prostate|1/1|
|skin|2/20|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|0/28|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1344
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OTUD5 Expression in NALM6 Cells: 5.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>