OXT [The Human Chemical-Genetic Interaction Map Project]

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======= OXT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: OXT
  * **<color #00a2e8>Official Name</color>**: oxytocin/neurophysin I prepropeptide
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5020|5020]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P01178|P01178]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=OXT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20OXT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/167050|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Neurophysin 1 specifically binds oxytocin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of hindgut contraction|
|oxytocin receptor binding|
|neurohypophyseal hormone activity|
|regulation of hindgut contraction|
|positive regulation of female receptivity|
|positive regulation of norepinephrine secretion|
|maternal aggressive behavior|
|sperm ejaculation|
|positive regulation of penile erection|
|negative regulation of urine volume|
|male mating behavior|
|response to disaccharide|
|response to sucrose|
|positive regulation of uterine smooth muscle contraction|
|negative regulation of gastric acid secretion|
|regulation of penile erection|
|regulation of female receptivity|
|aggressive behavior|
|female mating behavior|
|hyperosmotic salinity response|
|drinking behavior|
|positive regulation of prostaglandin secretion|
|positive regulation of digestive system process|
|regulation of uterine smooth muscle contraction|
|regulation of prostaglandin secretion|
|insemination|
|regulation of gastric acid secretion|
|response to ether|
|positive regulation of catecholamine secretion|
|maternal behavior|
|parental behavior|
|sleep|
|positive regulation of renal sodium excretion|
|grooming behavior|
|copulation|
|regulation of norepinephrine secretion|
|positive regulation of icosanoid secretion|
|positive regulation of fatty acid transport|
|negative regulation of digestive system process|
|regulation of icosanoid secretion|
|regulation of renal sodium excretion|
|mating behavior|
|response to food|
|regulation of urine volume|
|response to prostaglandin E|
|response to salt stress|
|regulation of excretion|
|hyperosmotic response|
|regulation of fatty acid transport|
|neuropeptide hormone activity|
|eating behavior|
|reproductive behavior|
|response to prostaglandin|
|positive regulation of smooth muscle contraction|
|response to amphetamine|
|mating|
|positive regulation of organic acid transport|
|regulation of renal system process|
|positive regulation of amine transport|
|positive regulation of blood pressure|
|regulation of sensory perception of pain|
|regulation of digestive system process|
|regulation of sensory perception|
|response to electrical stimulus|
|positive regulation of muscle contraction|
|negative regulation of blood pressure|
|response to progesterone|
|response to amine|
|terminal bouton|
|positive regulation of anion transport|
|response to bronchodilator|
|social behavior|
|intraspecies interaction between organisms|
|response to cocaine|
|regulation of organic acid transport|
|regulation of smooth muscle contraction|
|positive regulation of lipid transport|
|regulation of catecholamine secretion|
|response to activity|
|positive regulation of synapse assembly|
|multi-organism behavior|
|response to osmotic stress|
|positive regulation of reproductive process|
|response to anesthetic|
|positive regulation of lipid localization|
|positive regulation of ossification|
|response to fatty acid|
|feeding behavior|
|secretory granule|
|regulation of amine transport|
|regulation of anion transport|
|regulation of heart rate|
|positive regulation of cold-induced thermogenesis|
|response to cAMP|
|regulation of synapse assembly|
|regulation of lipid transport|
|response to retinoic acid|
|renal system process|
|response to alkaloid|
|memory|
|response to estradiol|
|response to organophosphorus|
|regulation of nervous system process|
|regulation of lipid localization|
|regulation of cold-induced thermogenesis|
|response to glucocorticoid|
|positive regulation of synaptic transmission|
|response to purine-containing compound|
|regulation of muscle contraction|
|regulation of reproductive process|
|response to corticosteroid|
|response to carbohydrate|
|female pregnancy|
|regulation of blood pressure|
|response to ammonium ion|
|regulation of ossification|
|response to ketone|
|multi-multicellular organism process|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|negative regulation of secretion|
|response to alcohol|
|regulation of muscle system process|
|regulation of heart contraction|
|learning or memory|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|cognition|
|response to xenobiotic stimulus|
|regulation of cytosolic calcium ion concentration|
|response to steroid hormone|
|response to acid chemical|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|negative regulation of transport|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|response to nutrient levels|
|response to toxic substance|
|positive regulation of multi-organism process|
|positive regulation of cellular component biogenesis|
|heart development|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|cellular metal ion homeostasis|
|behavior|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|circulatory system development|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|G protein-coupled receptor signaling pathway|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|homeostatic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9214
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='OXT Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>