P2RX2 [The Human Chemical-Genetic Interaction Map Project]

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======= P2RX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RX2
  * **<color #00a2e8>Official Name</color>**: purinergic receptor P2X 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22953|22953]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBL9|Q9UBL9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|P2X receptor|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of hypoxic conditions in blood by carotid body chemoreceptor signaling|
|regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling|
|regulation of systemic arterial blood pressure by chemoreceptor signaling|
|detection of hypoxic conditions in blood by chemoreceptor signaling|
|urinary bladder smooth muscle contraction|
|extracellularly ATP-gated cation channel activity|
|ATP-gated ion channel activity|
|urinary tract smooth muscle contraction|
|purinergic nucleotide receptor activity|
|peristalsis|
|nervous system process involved in regulation of systemic arterial blood pressure|
|ligand-gated ion channel activity|
|behavioral response to pain|
|integral component of nuclear inner membrane|
|phasic smooth muscle contraction|
|purinergic nucleotide receptor signaling pathway|
|skeletal muscle fiber development|
|myotube cell development|
|purinergic receptor signaling pathway|
|response to pain|
|response to ATP|
|neuromuscular synaptic transmission|
|neuromuscular junction development|
|positive regulation of calcium-mediated signaling|
|response to ischemia|
|smooth muscle contraction|
|positive regulation of calcium ion transport into cytosol|
|myotube differentiation|
|muscle fiber development|
|excitatory postsynaptic potential|
|chemical synaptic transmission, postsynaptic|
|sensory perception of taste|
|multicellular organismal response to stress|
|postsynapse|
|regulation of systemic arterial blood pressure|
|regulation of calcium-mediated signaling|
|regulation of calcium ion transport into cytosol|
|regulation of postsynaptic membrane potential|
|positive regulation of calcium ion transport|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|striated muscle cell development|
|response to organophosphorus|
|sensory perception of sound|
|muscle cell development|
|response to purine-containing compound|
|sensory perception of mechanical stimulus|
|response to carbohydrate|
|regulation of blood pressure|
|striated muscle cell differentiation|
|receptor complex|
|response to nutrient|
|muscle cell differentiation|
|regulation of calcium ion transport|
|muscle contraction|
|synapse organization|
|positive regulation of ion transport|
|positive regulation of cytosolic calcium ion concentration|
|striated muscle tissue development|
|blood coagulation|
|coagulation|
|muscle organ development|
|muscle tissue development|
|hemostasis|
|muscle system process|
|apical plasma membrane|
|regulation of cytosolic calcium ion concentration|
|protein homooligomerization|
|response to hypoxia|
|response to decreased oxygen levels|
|neuronal cell body|
|response to oxygen levels|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|trans-synaptic signaling|
|calcium ion homeostasis|
|synaptic signaling|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of body fluid levels|
|response to nutrient levels|
|protein complex oligomerization|
|detection of chemical stimulus|
|response to extracellular stimulus|
|sensory perception of chemical stimulus|
|cellular metal ion homeostasis|
|behavior|
|response to wounding|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|detection of stimulus|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|sensory perception|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|positive regulation of intracellular signal transduction|
|identical protein binding|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|ATP binding|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RX2 Expression in NALM6 Cells: -1.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>