P2RY2 [The Human Chemical-Genetic Interaction Map Project]

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======= P2RY2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: P2RY2
  * **<color #00a2e8>Official Name</color>**: purinergic receptor P2Y2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5029|5029]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41231|P41231]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=P2RY2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20P2RY2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600041|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mucus secretion|
|regulation of mucus secretion|
|G protein-coupled purinergic nucleotide receptor activity|
|G protein-coupled purinergic nucleotide receptor signaling pathway|
|cellular response to ATP|
|G protein-coupled purinergic receptor signaling pathway|
|purinergic nucleotide receptor signaling pathway|
|purinergic receptor signaling pathway|
|response to ATP|
|cellular response to nutrient|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|response to organophosphorus|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|response to purine-containing compound|
|vascular process in circulatory system|
|signaling receptor activity|
|response to nutrient|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|blood circulation|
|circulatory system process|
|cellular response to drug|
|positive regulation of secretion|
|regulation of body fluid levels|
|response to nutrient levels|
|regulation of anatomical structure size|
|response to extracellular stimulus|
|cellular response to organic cyclic compound|
|cellular response to organonitrogen compound|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of secretion|
|cellular homeostasis|
|response to organic cyclic compound|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of multicellular organismal process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.03|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.99|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15745
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='P2RY2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>