PACS1 [The Human Chemical-Genetic Interaction Map Project]

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======= PACS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PACS1
  * **<color #00a2e8>Official Name</color>**: phosphofurin acidic cluster sorting protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55690|55690]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6VY07|Q6VY07]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PACS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PACS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607492|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pacs-1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPI-coated vesicle|
|protein localization to Golgi apparatus|
|regulation of defense response to virus by virus|
|ion channel binding|
|protein localization to plasma membrane|
|protein localization to cell periphery|
|protein localization to membrane|
|viral process|
|protein localization to organelle|
|symbiotic process|
|interspecies interaction between organisms|
|Golgi apparatus|
|cellular protein localization|
|cellular macromolecule localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.89|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-2.29|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.04|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.86|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.78|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.82|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.83|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.84|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.89|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|1.89|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|1.89|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.89|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|1.95|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.98|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.99|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.99|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.24|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.26|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.29|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|2.38|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.61|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.66|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.67|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.82|
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.93|
|[[:results:exp134|MS023 2μM R03 exp134]]|3.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr37|WDR37]]|0.576|
|[[:human genes:c:cd19|CD19]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3785
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PACS1 Expression in NALM6 Cells: 5.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>