PADI2 [The Human Chemical-Genetic Interaction Map Project]

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======= PADI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PADI2
  * **<color #00a2e8>Official Name</color>**: peptidyl arginine deiminase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11240|11240]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2J8|Q9Y2J8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PADI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PADI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607935|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the deimination of arginine residues of proteins. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAD M|
|PAD|
|PAD N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-R26 citrullination|
|regulation of chromatin disassembly|
|negative regulation of lymphocyte chemotaxis|
|histone citrullination|
|protein citrullination|
|protein-arginine deiminase activity|
|negative regulation of chemokine-mediated signaling pathway|
|regulation of chromatin assembly or disassembly|
|regulation of chemokine-mediated signaling pathway|
|chromatin-mediated maintenance of transcription|
|negative regulation of lymphocyte migration|
|negative regulation of leukocyte chemotaxis|
|intracellular estrogen receptor signaling pathway|
|transcriptionally active chromatin|
|regulation of lymphocyte chemotaxis|
|peptidyl-arginine modification|
|substantia nigra development|
|estrogen receptor binding|
|negative regulation of leukocyte migration|
|negative regulation of chemotaxis|
|negative regulation of cytokine-mediated signaling pathway|
|neural nucleus development|
|regulation of lymphocyte migration|
|positive regulation of gene expression, epigenetic|
|negative regulation of response to cytokine stimulus|
|intracellular steroid hormone receptor signaling pathway|
|chromatin organization involved in regulation of transcription|
|midbrain development|
|azurophil granule lumen|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|regulation of leukocyte chemotaxis|
|steroid hormone mediated signaling pathway|
|intracellular receptor signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|hormone-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|cellular response to steroid hormone stimulus|
|regulation of chromatin organization|
|regulation of leukocyte migration|
|regulation of chemotaxis|
|regulation of gene expression, epigenetic|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|response to steroid hormone|
|regulation of chromosome organization|
|negative regulation of response to external stimulus|
|histone modification|
|covalent chromatin modification|
|negative regulation of immune system process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|cellular response to organic cyclic compound|
|myeloid leukocyte activation|
|cellular response to hormone stimulus|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|chromatin organization|
|regulated exocytosis|
|calcium ion binding|
|brain development|
|leukocyte mediated immunity|
|head development|
|exocytosis|
|regulation of cell migration|
|response to lipid|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|leukocyte activation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|chromosome organization|
|cell activation|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.41|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.07|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.94|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.72|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5024
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PADI2 Expression in NALM6 Cells: 1.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>