PAG1 [The Human Chemical-Genetic Interaction Map Project]

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======= PAG1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAG1
  * **<color #00a2e8>Official Name</color>**: phosphoprotein membrane anchor with glycosphingolipid microdomains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55824|55824]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWQ8|Q9NWQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAG1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAG1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605767|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SH2 domain binding|
|SH3/SH2 adaptor activity|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of lymphocyte activation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|T cell receptor signaling pathway|
|negative regulation of cell activation|
|membrane raft|
|negative regulation of cell adhesion|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of lymphocyte activation|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|activation of immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|positive regulation of immune response|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-3.12|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.9|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-2.89|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.29|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.2|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.17|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.14|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.06|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.99|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.92|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.91|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.86|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.83|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.81|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.79|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.78|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.75|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.71|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|1.75|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:csk|CSK]]|0.575|
|[[:human genes:p:pten|PTEN]]|0.457|
|[[:human genes:i:irf4|IRF4]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6619
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAG1 Expression in NALM6 Cells: 9.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>