PAM16 [The Human Chemical-Genetic Interaction Map Project]

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======= PAM16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PAM16
  * **<color #00a2e8>Official Name</color>**: presequence translocase associated motor 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51025|51025]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3D7|Q9Y3D7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAM16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAM16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614336|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein involved in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. This protein also plays a role in the import of nuclear-encoded mitochondrial proteins into the mitochondrial matrix and may be important in reactive oxygen species (ROS) homeostasis. Mutations in this gene cause Megarbane-Dagher-Melike type spondylometaphyseal dysplasia, an early lethal skeletal dysplasia characterized by short stature, developmental delay and other skeletal abnormalities. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity. {ECO:0000269|PubMed:20053669}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pam16|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of apoptotic DNA fragmentation|
|negative regulation of DNA catabolic process|
|PAM complex, Tim23 associated import motor|
|TIM23 mitochondrial import inner membrane translocase complex|
|regulation of apoptotic DNA fragmentation|
|regulation of DNA catabolic process|
|extrinsic component of mitochondrial inner membrane|
|protein import into mitochondrial matrix|
|negative regulation of ATPase activity|
|negative regulation of release of cytochrome c from mitochondria|
|negative regulation of execution phase of apoptosis|
|protein transmembrane import into intracellular organelle|
|regulation of execution phase of apoptosis|
|regulation of release of cytochrome c from mitochondria|
|intracellular protein transmembrane transport|
|negative regulation of mitochondrion organization|
|protein targeting to mitochondrion|
|protein transmembrane transport|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|regulation of ATPase activity|
|mitochondrial transmembrane transport|
|negative regulation of DNA metabolic process|
|protein import|
|regulation of mitochondrion organization|
|mitochondrial transport|
|negative regulation of apoptotic signaling pathway|
|negative regulation of cellular catabolic process|
|ossification|
|negative regulation of catabolic process|
|regulation of DNA metabolic process|
|protein targeting|
|mitochondrial matrix|
|negative regulation of organelle organization|
|regulation of apoptotic signaling pathway|
|establishment of protein localization to organelle|
|mitochondrion organization|
|negative regulation of hydrolase activity|
|protein-containing complex|
|negative regulation of cellular component organization|
|protein localization to organelle|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|intracellular protein transport|
|negative regulation of cell death|
|regulation of catabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|transmembrane transport|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of nucleobase-containing compound metabolic process|
|protein transport|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|negative regulation of response to stimulus|
|regulation of cell death|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.91|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.89|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.88|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.74|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.74|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.79|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.85|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.86|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.03|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.18|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|2.24|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.26|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.41|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:triap1|TRIAP1]]|0.591|
|[[:human genes:h:hars|HARS]]|0.581|
|[[:human genes:d:dpagt1|DPAGT1]]|0.576|
|[[:human genes:r:rnmt|RNMT]]|0.571|
|[[:human genes:r:rpn1|RPN1]]|0.561|
|[[:human genes:p:pelo|PELO]]|0.556|
|[[:human genes:h:hspd1|HSPD1]]|0.553|
|[[:human genes:r:rptor|RPTOR]]|0.551|
|[[:human genes:p:pmm2|PMM2]]|0.549|
|[[:human genes:g:gmppb|GMPPB]]|0.541|
|[[:human genes:a:alg2|ALG2]]|0.535|
|[[:human genes:a:alg1|ALG1]]|0.531|
|[[:human genes:d:dad1|DAD1]]|0.52|
|[[:human genes:v:vmp1|VMP1]]|0.519|
|[[:human genes:m:meaf6|MEAF6]]|0.519|
|[[:human genes:m:med16|MED16]]|0.516|
|[[:human genes:g:gfpt1|GFPT1]]|0.513|
|[[:human genes:a:aars|AARS]]|0.505|
|[[:human genes:u:uap1|UAP1]]|0.505|
|[[:human genes:t:tti2|TTI2]]|0.501|
|[[:human genes:d:ddost|DDOST]]|0.5|
|[[:human genes:h:hccs|HCCS]]|0.499|
|[[:human genes:t:thg1l|THG1L]]|0.497|
|[[:human genes:c:csnk2b|CSNK2B]]|0.496|
|[[:human genes:e:eprs|EPRS]]|0.493|
|[[:human genes:t:tamm41|TAMM41]]|0.492|
|[[:human genes:r:rtcb|RTCB]]|0.491|
|[[:human genes:o:oraov1|ORAOV1]]|0.48|
|[[:human genes:n:nars|NARS]]|0.479|
|[[:human genes:n:nae1|NAE1]]|0.479|
|[[:human genes:a:alg5|ALG5]]|0.478|
|[[:human genes:p:pisd|PISD]]|0.477|
|[[:human genes:s:srp72|SRP72]]|0.477|
|[[:human genes:d:dhps|DHPS]]|0.476|
|[[:human genes:e:exoc4|EXOC4]]|0.476|
|[[:human genes:e:eif4e|EIF4E]]|0.474|
|[[:human genes:c:ccdc101|CCDC101]]|0.474|
|[[:human genes:g:gnb1l|GNB1L]]|0.469|
|[[:human genes:d:dohh|DOHH]]|0.466|
|[[:human genes:n:nsmce1|NSMCE1]]|0.465|
|[[:human genes:r:rbm14|RBM14]]|0.464|
|[[:human genes:m:mtor|MTOR]]|0.462|
|[[:human genes:g:gtf3a|GTF3A]]|0.461|
|[[:human genes:c:cbfb|CBFB]]|0.458|
|[[:human genes:b:bap1|BAP1]]|0.455|
|[[:human genes:s:spcs2|SPCS2]]|0.454|
|[[:human genes:r:romo1|ROMO1]]|0.451|
|[[:human genes:t:tmem41b|TMEM41B]]|0.45|
|[[:human genes:c:casp9|CASP9]]|0.448|
|[[:human genes:p:plaa|PLAA]]|0.446|
|[[:human genes:e:eny2|ENY2]]|0.446|
|[[:human genes:h:haus8|HAUS8]]|0.446|
|[[:human genes:a:atxn10|ATXN10]]|0.445|
|[[:human genes:a:apaf1|APAF1]]|0.442|
|[[:human genes:t:tsen54|TSEN54]]|0.441|
|[[:human genes:o:osgep|OSGEP]]|0.441|
|[[:human genes:c:crls1|CRLS1]]|0.44|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.439|
|[[:human genes:w:wdr24|WDR24]]|0.438|
|[[:human genes:s:srp68|SRP68]]|0.436|
|[[:human genes:c:crcp|CRCP]]|0.436|
|[[:human genes:r:rpe|RPE]]|0.434|
|[[:human genes:p:polr3b|POLR3B]]|0.433|
|[[:human genes:t:tgs1|TGS1]]|0.432|
|[[:human genes:t:taz|TAZ]]|0.431|
|[[:human genes:d:ddx20|DDX20]]|0.43|
|[[:human genes:g:gemin5|GEMIN5]]|0.428|
|[[:human genes:c:cars|CARS]]|0.425|
|[[:human genes:m:mllt1|MLLT1]]|0.425|
|[[:human genes:c:cycs|CYCS]]|0.424|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.423|
|[[:human genes:s:srp14|SRP14]]|0.423|
|[[:human genes:t:trnt1|TRNT1]]|0.422|
|[[:human genes:n:nsd1|NSD1]]|0.42|
|[[:human genes:a:alg13|ALG13]]|0.42|
|[[:human genes:t:tbca|TBCA]]|0.42|
|[[:human genes:m:mars|MARS]]|0.419|
|[[:human genes:a:adsl|ADSL]]|0.418|
|[[:human genes:t:timm13|TIMM13]]|0.418|
|[[:human genes:s:spcs3|SPCS3]]|0.417|
|[[:human genes:p:pfn1|PFN1]]|0.416|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.415|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.415|
|[[:human genes:t:tsen2|TSEN2]]|0.415|
|[[:human genes:u:utp23|UTP23]]|0.414|
|[[:human genes:b:bub3|BUB3]]|0.413|
|[[:human genes:t:trmt5|TRMT5]]|0.413|
|[[:human genes:a:alg14|ALG14]]|0.412|
|[[:human genes:p:polr3h|POLR3H]]|0.412|
|[[:human genes:v:vrk1|VRK1]]|0.411|
|[[:human genes:t:tbcd|TBCD]]|0.409|
|[[:human genes:z:znf608|ZNF608]]|0.407|
|[[:human genes:e:exoc3|EXOC3]]|0.407|
|[[:human genes:d:dctn6|DCTN6]]|0.407|
|[[:human genes:r:rpp21|RPP21]]|0.404|
|[[:human genes:h:hspa9|HSPA9]]|0.402|
|[[:human genes:y:yars|YARS]]|0.402|
|[[:human genes:s:sdha|SDHA]]|0.401|
|[[:human genes:c:cdipt|CDIPT]]|0.401|
|[[:human genes:p:phb|PHB]]|0.401|
|[[:human genes:w:wars|WARS]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 729/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1525
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAM16 Expression in NALM6 Cells: 4.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>