PAPD5 [The Human Chemical-Genetic Interaction Map Project]

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======= PAPD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TENT4B
  * **<color #00a2e8>Official Name</color>**: terminal nucleotidyltransferase 4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64282|64282]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NDF8|Q8NDF8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PAPD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PAPD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605540|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAP assoc|
|NTP transf 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process|
|snoRNA polyadenylation|
|guanylyltransferase activity|
|ncRNA polyadenylation|
|negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|positive regulation of 3-UTR-mediated mRNA stabilization|
|regulation of 3-UTR-mediated mRNA stabilization|
|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|TRAMP complex|
|RNA 3 uridylation|
|miRNA catabolic process|
|polyadenylation-dependent ncRNA catabolic process|
|polynucleotide adenylyltransferase activity|
|polyadenylation-dependent RNA catabolic process|
|snoRNA 3-end processing|
|snoRNA processing|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|histone mRNA catabolic process|
|snoRNA metabolic process|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|negative regulation of telomere maintenance via telomerase|
|telomerase RNA binding|
|miRNA metabolic process|
|negative regulation of telomere maintenance via telomere lengthening|
|mRNA polyadenylation|
|DNA-directed DNA polymerase activity|
|histone mRNA metabolic process|
|ncRNA catabolic process|
|RNA polyadenylation|
|negative regulation of telomere maintenance|
|negative regulation of DNA biosynthetic process|
|ncRNA 3-end processing|
|negative regulation of mRNA catabolic process|
|regulation of telomere maintenance via telomerase|
|negative regulation of RNA catabolic process|
|regulation of telomere maintenance via telomere lengthening|
|negative regulation of mRNA metabolic process|
|mRNA 3-end processing|
|regulation of telomere maintenance|
|DNA biosynthetic process|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|negative regulation of chromosome organization|
|RNA 3-end processing|
|regulation of mRNA stability|
|regulation of RNA stability|
|carbohydrate homeostasis|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|rRNA processing|
|mRNA catabolic process|
|rRNA metabolic process|
|RNA catabolic process|
|negative regulation of cellular catabolic process|
|ribosome biogenesis|
|negative regulation of catabolic process|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|cell division|
|posttranscriptional regulation of gene expression|
|modification-dependent macromolecule catabolic process|
|mRNA metabolic process|
|negative regulation of cellular component organization|
|DNA metabolic process|
|regulation of cellular catabolic process|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|regulation of catabolic process|
|macromolecule catabolic process|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of gene expression|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.54|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.1|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|1.71|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.73|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.74|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.81|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.85|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.89|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3933
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PAPD5 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>