PARVA [The Human Chemical-Genetic Interaction Map Project]

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======= PARVA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PARVA
  * **<color #00a2e8>Official Name</color>**: parvin alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55742|55742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVD7|Q9NVD7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PARVA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PARVA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608120|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|smooth muscle cell chemotaxis|
|smooth muscle cell migration|
|muscle cell migration|
|outflow tract septum morphogenesis|
|heterotypic cell-cell adhesion|
|substrate adhesion-dependent cell spreading|
|sprouting angiogenesis|
|actin cytoskeleton reorganization|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|actin-mediated cell contraction|
|cardiac septum development|
|actin filament-based movement|
|cardiac chamber morphogenesis|
|Z disc|
|regulation of cell shape|
|cardiac chamber development|
|lamellipodium|
|cell-substrate adhesion|
|establishment or maintenance of cell polarity|
|cell chemotaxis|
|actin cytoskeleton|
|heart morphogenesis|
|actin binding|
|cadherin binding|
|angiogenesis|
|cilium assembly|
|cilium organization|
|blood vessel morphogenesis|
|focal adhesion|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|blood vessel development|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|heart development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|actin filament-based process|
|tube morphogenesis|
|cell morphogenesis|
|organelle assembly|
|cellular component morphogenesis|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|movement of cell or subcellular component|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.96|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.82|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.77|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11811
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PARVA Expression in NALM6 Cells: 2.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>