PCDH12 [The Human Chemical-Genetic Interaction Map Project]

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======= PCDH12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCDH12
  * **<color #00a2e8>Official Name</color>**: protocadherin 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51294|51294]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPG4|Q9NPG4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCDH12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCDH12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605622|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cadherin|
|Cadherin 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|
|labyrinthine layer development|
|neuron recognition|
|glycogen metabolic process|
|glucan metabolic process|
|cellular glucan metabolic process|
|energy reserve metabolic process|
|cellular polysaccharide metabolic process|
|polysaccharide metabolic process|
|embryonic placenta development|
|placenta development|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|cellular carbohydrate metabolic process|
|cell-cell junction|
|energy derivation by oxidation of organic compounds|
|cell recognition|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|in utero embryonic development|
|generation of precursor metabolites and energy|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|carbohydrate metabolic process|
|cell-cell adhesion|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|calcium ion binding|
|neuron development|
|cell adhesion|
|biological adhesion|
|oxidation-reduction process|
|embryo development|
|neuron differentiation|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|generation of neurons|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.569|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13987
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCDH12 Expression in NALM6 Cells: -0.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>