PCGF1 [The Human Chemical-Genetic Interaction Map Project]

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======= PCGF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCGF1
  * **<color #00a2e8>Official Name</color>**: polycomb group ring finger 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84759|84759]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BSM1|Q9BSM1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCGF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCGF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610231|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin- dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down- regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479). {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:16943429, ECO:0000269|PubMed:17088287, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:26687479}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H2A-K119 monoubiquitination|
|PRC1 complex|
|histone H2A monoubiquitination|
|histone H2A ubiquitination|
|PcG protein complex|
|histone monoubiquitination|
|histone ubiquitination|
|promoter-specific chromatin binding|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|protein monoubiquitination|
|chromatin organization involved in regulation of transcription|
|negative regulation of gene expression, epigenetic|
|gene silencing|
|protein C-terminus binding|
|regulation of gene expression, epigenetic|
|histone modification|
|covalent chromatin modification|
|protein ubiquitination|
|chromatin organization|
|protein modification by small protein conjugation|
|negative regulation of transcription by RNA polymerase II|
|protein modification by small protein conjugation or removal|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-3.19|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.96|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.96|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.88|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.73|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.66|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.48|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.44|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.43|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.39|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.31|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.31|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.29|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.28|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.26|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.19|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.14|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.12|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.09|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.06|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.06|
|[[:results:exp539|42°C R08 exp539]]|-2.05|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.98|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.97|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.97|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.94|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.93|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.93|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.92|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.91|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.89|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.88|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.86|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.83|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.81|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.76|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.75|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.74|
|[[:results:exp495|IWR1 50μM R08 exp495]]|1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.75|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.76|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.81|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.86|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.88|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.9|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.9|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.91|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.92|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.93|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.95|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.02|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.1|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|2.35|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.45|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.62|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.66|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.94|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|3.1|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|3.13|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|4.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ring1|RING1]]|0.678|
|[[:human genes:b:bcor|BCOR]]|0.675|
|[[:human genes:u:ube2e1|UBE2E1]]|0.581|
|[[:human genes:p:pds5b|PDS5B]]|0.509|
|[[:human genes:g:glyr1|GLYR1]]|0.505|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.503|
|[[:human genes:k:kdm6a|KDM6A]]|0.499|
|[[:human genes:a:arid4b|ARID4B]]|0.467|
|[[:human genes:a:anp32a|ANP32A]]|0.467|
|[[:human genes:p:pou2af1|POU2AF1]]|0.465|
|[[:human genes:c:cdk8|CDK8]]|0.464|
|[[:human genes:r:rbm26|RBM26]]|0.463|
|[[:human genes:i:ikzf2|IKZF2]]|0.456|
|[[:human genes:o:otub1|OTUB1]]|0.437|
|[[:human genes:c:cnot2|CNOT2]]|0.434|
|[[:human genes:b:brd1|BRD1]]|0.419|
|[[:human genes:w:wdr26|WDR26]]|0.415|
|[[:human genes:c:ctnnbl1|CTNNBL1]]|0.408|
|[[:human genes:g:gskip|GSKIP]]|0.406|
|[[:human genes:m:msi2|MSI2]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18986
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCGF1 Expression in NALM6 Cells: 3.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>