PCYOX1 [The Human Chemical-Genetic Interaction Map Project]

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======= PCYOX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PCYOX1
  * **<color #00a2e8>Official Name</color>**: prenylcysteine oxidase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51449|51449]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHG3|Q9UHG3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PCYOX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PCYOX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610995|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Prenylcys lyase|
|DAO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATPase-coupled chloride transmembrane transporter activity|
|prenylcysteine metabolic process|
|prenylcysteine oxidase activity|
|prenylcysteine catabolic process|
|prenylated protein catabolic process|
|sulfur amino acid catabolic process|
|very-low-density lipoprotein particle|
|cellular modified amino acid catabolic process|
|sulfur amino acid metabolic process|
|sulfur compound catabolic process|
|chloride transmembrane transport|
|chloride transport|
|inorganic anion transmembrane transport|
|cellular amino acid catabolic process|
|inorganic anion transport|
|cellular modified amino acid metabolic process|
|lysosome|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|anion transmembrane transport|
|cellular amino acid metabolic process|
|sulfur compound metabolic process|
|small molecule catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|anion transport|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|inorganic ion transmembrane transport|
|protein catabolic process|
|cellular macromolecule catabolic process|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|transmembrane transport|
|ion transport|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12017
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PCYOX1 Expression in NALM6 Cells: 6.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>