PDE2A [The Human Chemical-Genetic Interaction Map Project]

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======= PDE2A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE2A
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 2A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5138|5138]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00408|O00408]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE2A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE2A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602658|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDEase I|
|GAF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to 2,3,7,8-tetrachlorodibenzodioxine|
|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|
|response to 2,3,7,8-tetrachlorodibenzodioxine|
|cGMP catabolic process|
|negative regulation of cGMP-mediated signaling|
|cellular response to cGMP|
|response to cGMP|
|cellular response to macrophage colony-stimulating factor stimulus|
|TPR domain binding|
|response to macrophage colony-stimulating factor|
|positive regulation of vascular permeability|
|phosphate ion binding|
|negative regulation of vascular permeability|
|3,5-cyclic-AMP phosphodiesterase activity|
|cyclic nucleotide catabolic process|
|regulation of cGMP-mediated signaling|
|cGMP binding|
|3,5-cyclic-GMP phosphodiesterase activity|
|cGMP metabolic process|
|negative regulation of cAMP-mediated signaling|
|cAMP binding|
|cGMP-mediated signaling|
|purine ribonucleotide catabolic process|
|establishment of endothelial barrier|
|ribonucleotide catabolic process|
|regulation of vascular permeability|
|cyclic nucleotide metabolic process|
|purine nucleotide catabolic process|
|regulation of cAMP-mediated signaling|
|endothelial cell development|
|aorta development|
|purine-containing compound catabolic process|
|calcium channel activity|
|cellular response to cAMP|
|drug binding|
|heart valve development|
|nucleotide catabolic process|
|ventricular septum development|
|nucleoside phosphate catabolic process|
|presynaptic membrane|
|cellular response to mechanical stimulus|
|endothelial cell differentiation|
|adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway|
|artery development|
|endothelium development|
|response to cAMP|
|nucleobase-containing small molecule biosynthetic process|
|cardiac septum development|
|cardiac ventricle development|
|organophosphate catabolic process|
|response to organophosphorus|
|positive regulation of inflammatory response|
|cAMP-mediated signaling|
|response to purine-containing compound|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|mitochondrial outer membrane|
|vascular process in circulatory system|
|cardiac chamber development|
|cyclic-nucleotide-mediated signaling|
|regulation of mitochondrion organization|
|cellular response to xenobiotic stimulus|
|epithelial cell development|
|carbohydrate derivative catabolic process|
|calcium ion transmembrane transport|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|response to mechanical stimulus|
|magnesium ion binding|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|calcium ion transport|
|divalent metal ion transport|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|purine ribonucleotide metabolic process|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|cellular response to external stimulus|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|purine-containing compound metabolic process|
|mitochondrial matrix|
|nucleobase-containing compound catabolic process|
|blood circulation|
|circulatory system process|
|mitochondrial inner membrane|
|cellular response to drug|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|positive regulation of defense response|
|organic cyclic compound catabolic process|
|blood vessel development|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|inorganic cation transmembrane transport|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|perinuclear region of cytoplasm|
|regulation of defense response|
|cation transport|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to organic cyclic compound|
|ion transmembrane transport|
|Golgi apparatus|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|response to drug|
|carbohydrate derivative metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|epithelium development|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|transmembrane transport|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|cell development|
|intracellular signal transduction|
|negative regulation of gene expression|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.9|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11468
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE2A Expression in NALM6 Cells: -0.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>