PDE4D [The Human Chemical-Genetic Interaction Map Project]

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======= PDE4D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDE4D
  * **<color #00a2e8>Official Name</color>**: phosphodiesterase 4D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5144|5144]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08499|Q08499]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDE4D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDE4D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600129|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDEase I|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate|
|adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate|
|negative regulation of relaxation of cardiac muscle|
|positive regulation of heart rate by epinephrine-norepinephrine|
|adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process|
|beta-2 adrenergic receptor binding|
|negative regulation of relaxation of muscle|
|positive regulation of blood pressure by epinephrine-norepinephrine|
|regulation of relaxation of cardiac muscle|
|regulation of heart rate by chemical signal|
|G protein-coupled receptor signaling pathway involved in heart process|
|3,5-cyclic-nucleotide phosphodiesterase activity|
|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|
|cAMP catabolic process|
|regulation of cell communication by electrical coupling involved in cardiac conduction|
|regulation of relaxation of muscle|
|3,5-cyclic-AMP phosphodiesterase activity|
|regulation of cell communication by electrical coupling|
|positive regulation of interleukin-5 production|
|cellular response to epinephrine stimulus|
|cyclic nucleotide catabolic process|
|response to epinephrine|
|regulation of interleukin-5 production|
|cAMP metabolic process|
|cAMP binding|
|negative regulation of cAMP-mediated signaling|
|adenylate cyclase-activating adrenergic receptor signaling pathway|
|adrenergic receptor signaling pathway|
|calcium channel complex|
|positive regulation of heart rate|
|negative regulation of heart contraction|
|regulation of ryanodine-sensitive calcium-release channel activity|
|negative regulation of peptidyl-serine phosphorylation|
|voltage-gated calcium channel complex|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|positive regulation of interleukin-2 production|
|establishment of endothelial barrier|
|purine ribonucleotide catabolic process|
|ribonucleotide catabolic process|
|negative regulation of blood circulation|
|positive regulation of blood pressure|
|regulation of cardiac muscle cell contraction|
|positive regulation of heart contraction|
|cyclic nucleotide metabolic process|
|regulation of actin filament-based movement|
|purine nucleotide catabolic process|
|regulation of systemic arterial blood pressure mediated by a chemical signal|
|regulation of cAMP-mediated signaling|
|endothelial cell development|
|smooth muscle contraction|
|purine-containing compound catabolic process|
|regulation of interleukin-2 production|
|drug binding|
|scaffold protein binding|
|positive regulation of interferon-gamma production|
|nucleotide catabolic process|
|regulation of cardiac conduction|
|positive regulation of blood circulation|
|nucleoside phosphate catabolic process|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|ATPase binding|
|endothelial cell differentiation|
|multicellular organism growth|
|neutrophil chemotaxis|
|regulation of calcium ion transmembrane transporter activity|
|granulocyte chemotaxis|
|regulation of striated muscle contraction|
|neutrophil migration|
|regulation of systemic arterial blood pressure|
|endothelium development|
|regulation of heart rate|
|regulation of calcium-mediated signaling|
|regulation of interferon-gamma production|
|regulation of calcium ion transport into cytosol|
|granulocyte migration|
|heart process|
|cellular response to monoamine stimulus|
|cellular response to catecholamine stimulus|
|response to monoamine|
|response to catecholamine|
|nucleobase-containing small molecule biosynthetic process|
|regulation of sequestering of calcium ion|
|ion channel binding|
|organophosphate catabolic process|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|myeloid leukocyte migration|
|regulation of peptidyl-serine phosphorylation|
|leukocyte chemotaxis|
|cAMP-mediated signaling|
|regulation of calcium ion transmembrane transport|
|regulation of muscle contraction|
|regulation of cation channel activity|
|cyclic-nucleotide-mediated signaling|
|regulation of signaling receptor activity|
|T cell receptor signaling pathway|
|regulation of blood pressure|
|cellular response to lipopolysaccharide|
|carbohydrate derivative catabolic process|
|cellular response to molecule of bacterial origin|
|epithelial cell development|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|cell chemotaxis|
|cellular response to biotic stimulus|
|regulation of muscle system process|
|nuclear membrane|
|regulation of heart contraction|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of calcium ion transport|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|aging|
|regulation of blood circulation|
|antigen receptor-mediated signaling pathway|
|muscle system process|
|purine ribonucleotide metabolic process|
|response to lipopolysaccharide|
|apical plasma membrane|
|response to molecule of bacterial origin|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of cation transmembrane transport|
|ribose phosphate metabolic process|
|second-messenger-mediated signaling|
|enzyme binding|
|purine-containing compound metabolic process|
|nucleobase-containing compound catabolic process|
|leukocyte migration|
|regulation of metal ion transport|
|regulation of actin filament-based process|
|developmental growth|
|blood circulation|
|growth|
|circulatory system process|
|negative regulation of protein phosphorylation|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|negative regulation of phosphorylation|
|nucleotide metabolic process|
|positive regulation of cytokine production|
|immune response-activating cell surface receptor signaling pathway|
|nucleoside phosphate metabolic process|
|regulation of ion transmembrane transport|
|organic cyclic compound catabolic process|
|immune response-regulating cell surface receptor signaling pathway|
|centrosome|
|negative regulation of intracellular signal transduction|
|cellular response to lipid|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|chemotaxis|
|taxis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|small molecule biosynthetic process|
|regulation of system process|
|negative regulation of protein modification process|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|activation of immune response|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|response to bacterium|
|regulation of cytokine production|
|regulation of ion transport|
|response to lipid|
|positive regulation of immune response|
|organophosphate metabolic process|
|regulation of cellular localization|
|response to organic cyclic compound|
|cell migration|
|regulation of cellular component movement|
|response to organonitrogen compound|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|epithelium development|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|cell development|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.13|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.9|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.85|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.79|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.75|
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18652
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDE4D Expression in NALM6 Cells: 4.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>