PDIA4 [The Human Chemical-Genetic Interaction Map Project]

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======= PDIA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDIA4
  * **<color #00a2e8>Official Name</color>**: protein disulfide isomerase family A member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9601|9601]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13667|P13667]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDIA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDIA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620018|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thioredoxin|
|Calsequestrin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptide disulfide oxidoreductase activity|
|protein disulfide isomerase activity|
|chaperone-mediated protein folding|
|cell redox homeostasis|
|melanosome|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|protein folding|
|response to endoplasmic reticulum stress|
|endoplasmic reticulum lumen|
|cell surface|
|cellular homeostasis|
|oxidation-reduction process|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|secretion|
|RNA binding|
|protein transport|
|peptide transport|
|amide transport|
|extracellular space|
|establishment of protein localization|
|homeostatic process|
|cellular response to stress|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.89|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.77|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.72|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.82|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.88|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10286
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDIA4 Expression in NALM6 Cells: 8.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>