PDSS1 [The Human Chemical-Genetic Interaction Map Project]

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======= PDSS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDSS1
  * **<color #00a2e8>Official Name</color>**: decaprenyl diphosphate synthase subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23590|23590]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T2R2|Q5T2R2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDSS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDSS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607429|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. {ECO:0000269|PubMed:16262699}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|polyprenyl synt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trans-hexaprenyltranstransferase activity|
|trans-octaprenyltranstransferase activity|
|transferase complex|
|quinone biosynthetic process|
|ubiquinone biosynthetic process|
|ubiquinone metabolic process|
|isoprenoid biosynthetic process|
|ketone biosynthetic process|
|quinone metabolic process|
|protein heterotetramerization|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|protein heterooligomerization|
|coenzyme biosynthetic process|
|isoprenoid metabolic process|
|protein tetramerization|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|mitochondrial matrix|
|cofactor metabolic process|
|protein heterodimerization activity|
|protein complex oligomerization|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular lipid metabolic process|
|lipid metabolic process|
|protein-containing complex assembly|
|small molecule metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.67|
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-2.64|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.63|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.46|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.42|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-2.4|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.07|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-2.06|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.89|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.84|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|-1.75|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.74|
|[[:results:exp263|Aphidicolin 0.04μM R06 exp263]]|-1.72|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.72|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.7|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.77|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.84|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.85|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.85|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.86|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.88|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.89|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.9|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.93|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.97|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.99|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.03|
|[[:results:exp537|WNT3A 44ng/ml R08 exp537]]|2.14|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.18|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|2.2|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.22|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.24|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.24|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.3|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.38|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.64|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.65|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.78|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.81|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps21|MRPS21]]|0.604|
|[[:human genes:m:mrps5|MRPS5]]|0.603|
|[[:human genes:s:slc25a26|SLC25A26]]|0.582|
|[[:human genes:r:rpusd4|RPUSD4]]|0.582|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.568|
|[[:human genes:c:c17orf89|C17orf89]]|0.567|
|[[:human genes:s:sars2|SARS2]]|0.566|
|[[:human genes:m:mrpl21|MRPL21]]|0.566|
|[[:human genes:y:yars2|YARS2]]|0.565|
|[[:human genes:s:selrc1|SELRC1]]|0.565|
|[[:human genes:m:mrps16|MRPS16]]|0.564|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.563|
|[[:human genes:c:c12orf65|C12orf65]]|0.562|
|[[:human genes:m:mrpl23|MRPL23]]|0.561|
|[[:human genes:f:fastkd5|FASTKD5]]|0.561|
|[[:human genes:c:cox16|COX16]]|0.558|
|[[:human genes:m:mrpl53|MRPL53]]|0.552|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.548|
|[[:human genes:g:gatc|GATC]]|0.547|
|[[:human genes:m:mrps6|MRPS6]]|0.546|
|[[:human genes:m:mrps34|MRPS34]]|0.539|
|[[:human genes:c:coq2|COQ2]]|0.535|
|[[:human genes:t:tefm|TEFM]]|0.535|
|[[:human genes:m:mrps18a|MRPS18A]]|0.534|
|[[:human genes:n:ndufb3|NDUFB3]]|0.53|
|[[:human genes:m:mrp63|MRP63]]|0.529|
|[[:human genes:t:triap1|TRIAP1]]|0.527|
|[[:human genes:d:dap3|DAP3]]|0.525|
|[[:human genes:b:bcs1l|BCS1L]]|0.522|
|[[:human genes:a:atp5d|ATP5D]]|0.521|
|[[:human genes:c:cox6c|COX6C]]|0.52|
|[[:human genes:c:chchd4|CHCHD4]]|0.52|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.519|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.516|
|[[:human genes:q:qrsl1|QRSL1]]|0.516|
|[[:human genes:r:rars2|RARS2]]|0.515|
|[[:human genes:g:gfm1|GFM1]]|0.515|
|[[:human genes:t:tufm|TUFM]]|0.51|
|[[:human genes:m:mrps14|MRPS14]]|0.509|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.508|
|[[:human genes:m:mrpl15|MRPL15]]|0.506|
|[[:human genes:d:dars2|DARS2]]|0.506|
|[[:human genes:a:atp5sl|ATP5SL]]|0.506|
|[[:human genes:n:ndufb5|NDUFB5]]|0.505|
|[[:human genes:m:mrpl12|MRPL12]]|0.505|
|[[:human genes:m:mtg2|MTG2]]|0.503|
|[[:human genes:v:vars2|VARS2]]|0.501|
|[[:human genes:h:hars2|HARS2]]|0.497|
|[[:human genes:t:tmem242|TMEM242]]|0.496|
|[[:human genes:m:mrps9|MRPS9]]|0.495|
|[[:human genes:m:mtpap|MTPAP]]|0.494|
|[[:human genes:m:mrpl47|MRPL47]]|0.494|
|[[:human genes:e:ears2|EARS2]]|0.487|
|[[:human genes:c:coq7|COQ7]]|0.487|
|[[:human genes:c:cox7b|COX7B]]|0.486|
|[[:human genes:n:ndufb11|NDUFB11]]|0.485|
|[[:human genes:p:pars2|PARS2]]|0.485|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.484|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.482|
|[[:human genes:t:tars2|TARS2]]|0.482|
|[[:human genes:m:mrps25|MRPS25]]|0.482|
|[[:human genes:s:sco2|SCO2]]|0.482|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.481|
|[[:human genes:m:mrps26|MRPS26]]|0.479|
|[[:human genes:p:pmm2|PMM2]]|0.478|
|[[:human genes:r:rbfa|RBFA]]|0.478|
|[[:human genes:m:mrpl55|MRPL55]]|0.477|
|[[:human genes:a:atp5b|ATP5B]]|0.477|
|[[:human genes:g:gfm2|GFM2]]|0.477|
|[[:human genes:w:wbscr16|WBSCR16]]|0.476|
|[[:human genes:r:rpia|RPIA]]|0.476|
|[[:human genes:c:c10orf2|C10orf2]]|0.475|
|[[:human genes:t:trmt10a|TRMT10A]]|0.474|
|[[:human genes:c:coq4|COQ4]]|0.474|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.473|
|[[:human genes:c:crls1|CRLS1]]|0.472|
|[[:human genes:n:ndufc2|NDUFC2]]|0.472|
|[[:human genes:n:nars2|NARS2]]|0.47|
|[[:human genes:c:cox17|COX17]]|0.47|
|[[:human genes:m:mtif3|MTIF3]]|0.47|
|[[:human genes:m:mrps33|MRPS33]]|0.469|
|[[:human genes:c:coq3|COQ3]]|0.469|
|[[:human genes:n:ndufa3|NDUFA3]]|0.465|
|[[:human genes:t:taz|TAZ]]|0.465|
|[[:human genes:m:mrps12|MRPS12]]|0.465|
|[[:human genes:m:mrps24|MRPS24]]|0.464|
|[[:human genes:a:alg6|ALG6]]|0.463|
|[[:human genes:c:cep57|CEP57]]|0.463|
|[[:human genes:r:romo1|ROMO1]]|0.46|
|[[:human genes:l:lars2|LARS2]]|0.459|
|[[:human genes:t:trub2|TRUB2]]|0.458|
|[[:human genes:t:tmem126b|TMEM126B]]|0.458|
|[[:human genes:r:rpusd3|RPUSD3]]|0.457|
|[[:human genes:t:trnt1|TRNT1]]|0.457|
|[[:human genes:a:atp5o|ATP5O]]|0.456|
|[[:human genes:t:timm8b|TIMM8B]]|0.453|
|[[:human genes:t:tpk1|TPK1]]|0.453|
|[[:human genes:t:tmem261|TMEM261]]|0.453|
|[[:human genes:c:coq6|COQ6]]|0.453|
|[[:human genes:t:tomm22|TOMM22]]|0.452|
|[[:human genes:d:dpagt1|DPAGT1]]|0.452|
|[[:human genes:a:atp5a1|ATP5A1]]|0.45|
|[[:human genes:m:mrpl18|MRPL18]]|0.45|
|[[:human genes:f:fh|FH]]|0.45|
|[[:human genes:t:tomm40|TOMM40]]|0.449|
|[[:human genes:t:thg1l|THG1L]]|0.449|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.449|
|[[:human genes:p:pnpt1|PNPT1]]|0.449|
|[[:human genes:u:uqcr10|UQCR10]]|0.448|
|[[:human genes:n:ndufa2|NDUFA2]]|0.441|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.438|
|[[:human genes:c:coa6|COA6]]|0.437|
|[[:human genes:c:cox6b1|COX6B1]]|0.437|
|[[:human genes:m:mrpl34|MRPL34]]|0.435|
|[[:human genes:m:mrps2|MRPS2]]|0.435|
|[[:human genes:d:dnlz|DNLZ]]|0.433|
|[[:human genes:l:lsm10|LSM10]]|0.432|
|[[:human genes:c:coa5|COA5]]|0.432|
|[[:human genes:m:mrps23|MRPS23]]|0.432|
|[[:human genes:n:ndufb9|NDUFB9]]|0.431|
|[[:human genes:n:ndufs7|NDUFS7]]|0.43|
|[[:human genes:a:alg13|ALG13]]|0.43|
|[[:human genes:a:adsl|ADSL]]|0.429|
|[[:human genes:a:aifm1|AIFM1]]|0.427|
|[[:human genes:m:mrpl36|MRPL36]]|0.427|
|[[:human genes:r:rpe|RPE]]|0.427|
|[[:human genes:m:mrps17|MRPS17]]|0.427|
|[[:human genes:m:mrps10|MRPS10]]|0.427|
|[[:human genes:n:ndufb1|NDUFB1]]|0.427|
|[[:human genes:p:pgm3|PGM3]]|0.426|
|[[:human genes:n:ndufa11|NDUFA11]]|0.424|
|[[:human genes:f:ftsj2|FTSJ2]]|0.423|
|[[:human genes:a:alg1|ALG1]]|0.422|
|[[:human genes:f:fars2|FARS2]]|0.422|
|[[:human genes:n:ndufb6|NDUFB6]]|0.422|
|[[:human genes:u:uqcrq|UQCRQ]]|0.421|
|[[:human genes:m:mrps7|MRPS7]]|0.421|
|[[:human genes:a:atp5j|ATP5J]]|0.421|
|[[:human genes:m:minos1|MINOS1]]|0.419|
|[[:human genes:a:atp5c1|ATP5C1]]|0.419|
|[[:human genes:e:elac2|ELAC2]]|0.418|
|[[:human genes:c:cox5a|COX5A]]|0.417|
|[[:human genes:c:coa3|COA3]]|0.417|
|[[:human genes:n:ndufa1|NDUFA1]]|0.416|
|[[:human genes:m:mrpl27|MRPL27]]|0.416|
|[[:human genes:m:mrpl22|MRPL22]]|0.415|
|[[:human genes:p:ppcs|PPCS]]|0.415|
|[[:human genes:t:tamm41|TAMM41]]|0.414|
|[[:human genes:h:hccs|HCCS]]|0.411|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.408|
|[[:human genes:m:mrpl44|MRPL44]]|0.408|
|[[:human genes:a:atxn10|ATXN10]]|0.408|
|[[:human genes:d:dhx30|DHX30]]|0.407|
|[[:human genes:o:opa1|OPA1]]|0.406|
|[[:human genes:m:mrpl45|MRPL45]]|0.406|
|[[:human genes:a:atp5h|ATP5H]]|0.405|
|[[:human genes:p:polg|POLG]]|0.404|
|[[:human genes:e:ecsit|ECSIT]]|0.404|
|[[:human genes:m:mrps22|MRPS22]]|0.403|
|[[:human genes:m:mars2|MARS2]]|0.402|
|[[:human genes:g:glrx5|GLRX5]]|0.402|
|[[:human genes:c:cox10|COX10]]|0.402|
|[[:human genes:g:gemin7|GEMIN7]]|0.402|
|[[:human genes:p:pdss2|PDSS2]]|0.401|
|[[:human genes:c:coq5|COQ5]]|0.401|
|[[:human genes:m:mtg1|MTG1]]|0.4|
|[[:human genes:n:ndufb7|NDUFB7]]|0.4|
|[[:human genes:u:uqcc2|UQCC2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3289
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDSS1 Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>