PDXP [The Human Chemical-Genetic Interaction Map Project]

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======= PDXP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDXP
  * **<color #00a2e8>Official Name</color>**: pyridoxal phosphatase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57026|57026]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96GD0|Q96GD0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDXP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDXP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609246|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'- phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (PubMed:14522954). {ECO:0000269|PubMed:14522954, ECO:0000269|PubMed:15580268}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hydrolase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vitamin B6 catabolic process|
|pyridoxal phosphate catabolic process|
|actin rod assembly|
|pyridoxal phosphatase activity|
|water-soluble vitamin catabolic process|
|phosphoserine phosphatase activity|
|pyridoxal phosphate metabolic process|
|vitamin B6 metabolic process|
|contractile ring|
|pyridine-containing compound catabolic process|
|aldehyde catabolic process|
|vitamin catabolic process|
|positive regulation of actin filament depolymerization|
|coenzyme catabolic process|
|cellular response to ATP|
|positive regulation of protein depolymerization|
|lamellipodium membrane|
|response to ATP|
|positive regulation of protein complex disassembly|
|phosphoprotein phosphatase activity|
|pyridine-containing compound metabolic process|
|phosphatase activity|
|regulation of actin filament depolymerization|
|cellular aldehyde metabolic process|
|cleavage furrow|
|heat shock protein binding|
|cofactor catabolic process|
|actin filament bundle assembly|
|actin filament bundle organization|
|cellular response to nutrient|
|organic hydroxy compound catabolic process|
|regulation of protein depolymerization|
|water-soluble vitamin metabolic process|
|regulation of cytokinesis|
|ruffle membrane|
|regulation of protein complex disassembly|
|vitamin metabolic process|
|organophosphate catabolic process|
|response to organophosphorus|
|drug catabolic process|
|response to purine-containing compound|
|midbody|
|regulation of cell division|
|regulation of mitotic nuclear division|
|cell-cell junction|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of nuclear division|
|positive regulation of supramolecular fiber organization|
|protein dephosphorylation|
|magnesium ion binding|
|response to nutrient|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|cellular response to nutrient levels|
|actin filament organization|
|coenzyme metabolic process|
|regulation of actin filament organization|
|cellular response to extracellular stimulus|
|dephosphorylation|
|cellular response to external stimulus|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|cellular response to drug|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|supramolecular fiber organization|
|organic cyclic compound catabolic process|
|actin cytoskeleton organization|
|response to nutrient levels|
|drug metabolic process|
|regulation of anatomical structure size|
|response to extracellular stimulus|
|regulation of cytoskeleton organization|
|cellular response to organic cyclic compound|
|actin filament-based process|
|cellular response to organonitrogen compound|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|cellular response to nitrogen compound|
|regulation of cell cycle process|
|protein homodimerization activity|
|organophosphate metabolic process|
|response to organic cyclic compound|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|cytoskeleton organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17281
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDXP Expression in NALM6 Cells: 5.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>