PDZD11 [The Human Chemical-Genetic Interaction Map Project]

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======= PDZD11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PDZD11
  * **<color #00a2e8>Official Name</color>**: PDZ domain containing 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51248|51248]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5EBL8|Q5EBL8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PDZD11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PDZD11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300632|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pantothenate metabolic process|
|protein localization to basolateral plasma membrane|
|biotin metabolic process|
|maintenance of apical/basal cell polarity|
|maintenance of epithelial cell apical/basal polarity|
|pore complex|
|maintenance of cell polarity|
|pore complex assembly|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|water-soluble vitamin metabolic process|
|presynapse|
|signal release from synapse|
|neurotransmitter secretion|
|antimicrobial humoral response|
|vitamin metabolic process|
|signal release|
|cell-cell junction|
|neurotransmitter transport|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|cellular modified amino acid metabolic process|
|protein localization to cell periphery|
|coenzyme metabolic process|
|synapse|
|humoral immune response|
|regulation of neurotransmitter levels|
|sulfur compound metabolic process|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|cofactor metabolic process|
|synaptic signaling|
|protein localization to membrane|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|secretion by cell|
|organic acid metabolic process|
|export from cell|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|ion transport|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|small molecule metabolic process|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.95|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12048
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PDZD11 Expression in NALM6 Cells: 3.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>