PECAM1 [The Human Chemical-Genetic Interaction Map Project]

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======= PECAM1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PECAM1
  * **<color #00a2e8>Official Name</color>**: platelet and endothelial cell adhesion molecule 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5175|5175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16284|P16284]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PECAM1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PECAM1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173445|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endothelial cell-matrix adhesion|
|glomerular endothelium development|
|smooth muscle contractile fiber|
|monocyte extravasation|
|neutrophil extravasation|
|diapedesis|
|endothelial cell morphogenesis|
|platelet alpha granule membrane|
|glomerulus vasculature development|
|glomerular epithelium development|
|kidney vasculature development|
|renal system vasculature development|
|cell-cell contact zone|
|epithelial cell morphogenesis|
|bicellular tight junction assembly|
|tight junction assembly|
|cellular extravasation|
|tight junction organization|
|apical junction assembly|
|mononuclear cell migration|
|endothelial cell development|
|leukocyte cell-cell adhesion|
|glomerulus development|
|endothelial cell migration|
|positive regulation of tyrosine phosphorylation of STAT protein|
|Rho protein signal transduction|
|regulation of tyrosine phosphorylation of STAT protein|
|endothelial cell differentiation|
|epithelial cell migration|
|positive regulation of receptor signaling pathway via JAK-STAT|
|epithelium migration|
|positive regulation of receptor signaling pathway via STAT|
|neutrophil migration|
|tissue migration|
|endothelium development|
|nephron epithelium development|
|secretory granule membrane|
|granulocyte migration|
|cell-cell junction assembly|
|nephron development|
|cell-matrix adhesion|
|myeloid leukocyte migration|
|kidney epithelium development|
|platelet degranulation|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|cell-cell junction organization|
|cell junction assembly|
|homophilic cell adhesion via plasma membrane adhesion molecules|
|ameboidal-type cell migration|
|cell-cell junction|
|cell-substrate adhesion|
|positive regulation of peptidyl-tyrosine phosphorylation|
|epithelial cell development|
|cell junction organization|
|membrane raft|
|cell recognition|
|Ras protein signal transduction|
|regulation of peptidyl-tyrosine phosphorylation|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|kidney development|
|renal system development|
|angiogenesis|
|urogenital system development|
|small GTPase mediated signal transduction|
|phagocytosis|
|extracellular matrix organization|
|leukocyte migration|
|extracellular structure organization|
|external side of plasma membrane|
|blood vessel morphogenesis|
|wound healing|
|blood vessel development|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|vasculature development|
|leukocyte degranulation|
|cardiovascular system development|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|response to wounding|
|myeloid leukocyte activation|
|protein-containing complex|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|tube morphogenesis|
|epithelial cell differentiation|
|regulated exocytosis|
|cell morphogenesis|
|leukocyte mediated immunity|
|exocytosis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|epithelium development|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|locomotion|
|regulation of protein phosphorylation|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11527
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PECAM1 Expression in NALM6 Cells: 2.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>