PET100 [The Human Chemical-Genetic Interaction Map Project]

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======= PET100 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PET100
  * **<color #00a2e8>Official Name</color>**: PET100 cytochrome c oxidase chaperone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=100131801|100131801]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0DJ07|P0DJ07]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PET100&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PET100|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614770|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mitochondrial complex IV, or cytochrome c oxidase, is a large transmembrane protein complex that is part of the respiratory electron transport chain of mitochondria. The small protein encoded by this gene plays a role in the biogenesis of mitochondrial complex IV. This protein localizes to the inner mitochondrial membrane and is exposed to the intermembrane space. Mutations in this gene are associated with mitochondrial complex IV deficiency. This gene has a pseudogene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2346|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|integral component of mitochondrial inner membrane|
|mitochondrial respiratory chain complex assembly|
|unfolded protein binding|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.71|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.72|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.78|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.85|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.87|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox16|COX16]]|0.558|
|[[:human genes:f:fastkd5|FASTKD5]]|0.524|
|[[:human genes:s:sco2|SCO2]]|0.523|
|[[:human genes:m:mrps16|MRPS16]]|0.492|
|[[:human genes:s:selrc1|SELRC1]]|0.487|
|[[:human genes:b:bcs1l|BCS1L]]|0.476|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.474|
|[[:human genes:y:yars2|YARS2]]|0.473|
|[[:human genes:m:mrpl21|MRPL21]]|0.469|
|[[:human genes:e:ears2|EARS2]]|0.469|
|[[:human genes:l:lars2|LARS2]]|0.465|
|[[:human genes:m:mrps33|MRPS33]]|0.443|
|[[:human genes:r:rpusd4|RPUSD4]]|0.438|
|[[:human genes:d:dap3|DAP3]]|0.438|
|[[:human genes:q:qrsl1|QRSL1]]|0.437|
|[[:human genes:n:nars2|NARS2]]|0.437|
|[[:human genes:m:mrps2|MRPS2]]|0.433|
|[[:human genes:m:mrps14|MRPS14]]|0.432|
|[[:human genes:p:pars2|PARS2]]|0.432|
|[[:human genes:m:mrpl47|MRPL47]]|0.431|
|[[:human genes:t:tars2|TARS2]]|0.429|
|[[:human genes:g:gatc|GATC]]|0.428|
|[[:human genes:m:mrps6|MRPS6]]|0.427|
|[[:human genes:d:dars2|DARS2]]|0.424|
|[[:human genes:t:tmem242|TMEM242]]|0.423|
|[[:human genes:c:cox6c|COX6C]]|0.423|
|[[:human genes:m:mrps5|MRPS5]]|0.421|
|[[:human genes:c:cox17|COX17]]|0.421|
|[[:human genes:m:mrps24|MRPS24]]|0.42|
|[[:human genes:c:coa6|COA6]]|0.419|
|[[:human genes:m:mrpl53|MRPL53]]|0.418|
|[[:human genes:c:cox11|COX11]]|0.416|
|[[:human genes:p:polg2|POLG2]]|0.413|
|[[:human genes:c:coq4|COQ4]]|0.41|
|[[:human genes:c:c10orf2|C10orf2]]|0.41|
|[[:human genes:c:coa3|COA3]]|0.409|
|[[:human genes:p:polg|POLG]]|0.409|
|[[:human genes:g:gfm1|GFM1]]|0.408|
|[[:human genes:m:mrps21|MRPS21]]|0.407|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.407|
|[[:human genes:d:dhx30|DHX30]]|0.404|
|[[:human genes:c:c17orf89|C17orf89]]|0.402|
|[[:human genes:p:pet117|PET117]]|0.402|
|[[:human genes:m:mtg2|MTG2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3333
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PET100 Expression in NALM6 Cells: 3.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>