PEX13 [The Human Chemical-Genetic Interaction Map Project]

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======= PEX13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEX13
  * **<color #00a2e8>Official Name</color>**: peroxisomal biogenesis factor 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5194|5194]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92968|Q92968]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEX13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEX13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601789|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a peroxisomal membrane protein that binds the type 1 peroxisomal targeting signal receptor via a SH3 domain located in the cytoplasm. Mutations and deficiencies in peroxisomal protein importing and peroxisome assembly lead to peroxisomal biogenesis disorders, an example of which is Zellweger syndrome. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 1|
|Peroxin-13 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peroxisome localization|
|microtubule-based peroxisome localization|
|peroxisomal importomer complex|
|protein import into peroxisome matrix, docking|
|fatty acid alpha-oxidation|
|suckling behavior|
|protein import into peroxisome matrix|
|integral component of peroxisomal membrane|
|peroxisomal membrane transport|
|protein transmembrane import into intracellular organelle|
|cerebral cortex cell migration|
|intracellular protein transmembrane transport|
|peroxisomal membrane|
|telencephalon cell migration|
|protein transmembrane transport|
|forebrain cell migration|
|multi-organism behavior|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|fatty acid oxidation|
|lipid oxidation|
|peroxisome organization|
|feeding behavior|
|fatty acid catabolic process|
|peroxisome|
|cerebral cortex development|
|monocarboxylic acid catabolic process|
|neuron migration|
|protein import|
|pallium development|
|cellular lipid catabolic process|
|locomotory behavior|
|lipid modification|
|telencephalon development|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|lipid catabolic process|
|fatty acid metabolic process|
|protein targeting|
|forebrain development|
|establishment of protein localization to organelle|
|small molecule catabolic process|
|monocarboxylic acid metabolic process|
|behavior|
|organelle localization|
|microtubule-based process|
|intracellular membrane-bounded organelle|
|protein ubiquitination|
|protein localization to organelle|
|brain development|
|protein modification by small protein conjugation|
|head development|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|cell migration|
|oxidation-reduction process|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|oxoacid metabolic process|
|organic acid metabolic process|
|cell motility|
|localization of cell|
|lipid metabolic process|
|transmembrane transport|
|locomotion|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.14|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.73|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-1.72|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.7|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.71|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.8|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.22|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.34|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.35|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pex12|PEX12]]|0.573|
|[[:human genes:p:pex1|PEX1]]|0.544|
|[[:human genes:p:pex6|PEX6]]|0.512|
|[[:human genes:p:pex7|PEX7]]|0.499|
|[[:human genes:p:pex10|PEX10]]|0.479|
|[[:human genes:p:pex5|PEX5]]|0.473|
|[[:human genes:a:agps|AGPS]]|0.452|
|[[:human genes:p:pex3|PEX3]]|0.452|
|[[:human genes:p:pex2|PEX2]]|0.448|
|[[:human genes:p:pex26|PEX26]]|0.419|
|[[:human genes:p:pex19|PEX19]]|0.409|
|[[:human genes:p:polr2j3|POLR2J3]]|0.406|
|[[:human genes:p:pex14|PEX14]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5788
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEX13 Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>