PEX1 [The Human Chemical-Genetic Interaction Map Project]

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======= PEX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PEX1
  * **<color #00a2e8>Official Name</color>**: peroxisomal biogenesis factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5189|5189]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43933|O43933]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PEX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PEX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602136|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AAA|
|PEX-1N|
|PEX-2N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peroxisome localization|
|microtubule-based peroxisome localization|
|protein import into peroxisome matrix|
|peroxisomal membrane transport|
|ATPase activity, coupled|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|peroxisomal membrane|
|protein transmembrane transport|
|establishment of protein localization to peroxisome|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|peroxisomal transport|
|peroxisome organization|
|peroxisome|
|protein import|
|protein C-terminus binding|
|ATPase activity|
|protein-containing complex binding|
|protein targeting|
|establishment of protein localization to organelle|
|organelle localization|
|microtubule-based process|
|protein localization to organelle|
|intracellular protein transport|
|transmembrane transport|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.75|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.66|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.52|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.06|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-2.04|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.99|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.93|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.65|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pex12|PEX12]]|0.636|
|[[:human genes:p:pex7|PEX7]]|0.61|
|[[:human genes:p:pex2|PEX2]]|0.568|
|[[:human genes:p:pex13|PEX13]]|0.544|
|[[:human genes:p:pex6|PEX6]]|0.538|
|[[:human genes:p:pex14|PEX14]]|0.522|
|[[:human genes:p:pex3|PEX3]]|0.511|
|[[:human genes:a:agps|AGPS]]|0.507|
|[[:human genes:p:pex10|PEX10]]|0.491|
|[[:human genes:p:pex26|PEX26]]|0.475|
|[[:human genes:l:ldlrap1|LDLRAP1]]|0.453|
|[[:human genes:g:gnpat|GNPAT]]|0.452|
|[[:human genes:p:pex19|PEX19]]|0.443|
|[[:human genes:t:tmem189|TMEM189]]|0.435|
|[[:human genes:l:ldlr|LDLR]]|0.435|
|[[:human genes:p:pex5|PEX5]]|0.42|
|[[:human genes:a:acsl4|ACSL4]]|0.413|
|[[:human genes:p:pcyt2|PCYT2]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 9/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8642
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PEX1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>