PGAM2 [The Human Chemical-Genetic Interaction Map Project]

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======= PGAM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: PGAM2
  * **<color #00a2e8>Official Name</color>**: phosphoglycerate mutase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5224|5224]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15259|P15259]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=PGAM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20PGAM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612931|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|His Phos 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|
|bisphosphoglycerate mutase activity|
|phosphoglycerate mutase activity|
|response to mercury ion|
|cofactor binding|
|NADH regeneration|
|glucose catabolic process to pyruvate|
|canonical glycolysis|
|glycolytic process through glucose-6-phosphate|
|glycolytic process through fructose-6-phosphate|
|glucose catabolic process|
|NADH metabolic process|
|glycolytic process|
|ATP generation from ADP|
|gluconeogenesis|
|NAD metabolic process|
|hexose biosynthetic process|
|ADP metabolic process|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|nucleoside diphosphate phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|nucleotide phosphorylation|
|monosaccharide catabolic process|
|purine nucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|hydrolase activity|
|nucleoside diphosphate metabolic process|
|striated muscle contraction|
|glucose metabolic process|
|carbohydrate catabolic process|
|Notch signaling pathway|
|carbohydrate biosynthetic process|
|hexose metabolic process|
|monosaccharide metabolic process|
|ATP metabolic process|
|muscle contraction|
|muscle system process|
|purine ribonucleotide metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|response to metal ion|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|response to inorganic substance|
|nucleobase-containing small molecule metabolic process|
|spermatogenesis|
|male gamete generation|
|small molecule biosynthetic process|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|phosphorylation|
|reproductive process|
|reproduction|
|small molecule metabolic process|
|organic substance catabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.72|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.05|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.19|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|3.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9860
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='PGAM2 Expression in NALM6 Cells: 0.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>